Please use this identifier to cite or link to this item:
https://doi.org/10.18632/oncotarget.10091
DC Field | Value | |
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dc.title | White matter degeneration in subjective cognitive decline: A diffusion tensor imaging study | |
dc.contributor.author | Li, X.-Y | |
dc.contributor.author | Tang, Z.-C | |
dc.contributor.author | Sun, Y | |
dc.contributor.author | Tian, J | |
dc.contributor.author | Liu, Z.-Y | |
dc.contributor.author | Han, Y | |
dc.date.accessioned | 2020-10-26T08:45:05Z | |
dc.date.available | 2020-10-26T08:45:05Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Li, X.-Y, Tang, Z.-C, Sun, Y, Tian, J, Liu, Z.-Y, Han, Y (2016). White matter degeneration in subjective cognitive decline: A diffusion tensor imaging study. Oncotarget 7 (34) : 54405-54414. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.10091 | |
dc.identifier.issn | 1949-2553 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/180386 | |
dc.description.abstract | Subjective cognitive decline (SCD) may be an at-risk stage of Alzheimer's disease (AD) occurring prior to amnestic mild cognitive impairment (aMCI). To examine white matter (WM) defects in SCD, diffusion images from 27 SCD (age=65.3±8.0), 35 aMCI (age=69.2±8.6) and 25 AD patients (age=68.3±9.4) and 37 normal controls (NC) (age=65.1±6.8) were compared using Tract-Based Spatial Statistics (TBSS). WM impairments common to the three patient groups were extracted, and fractional anisotropy (FA) values were averaged in each group. As compared to NC subjects, SCD patients displayed widespread WM alterations represented by decreased FA (p < 0.05), increased mean diffusivity (MD; p < 0.05), and increased radial diffusivity (RD; p < 0.05). In addition, localized WM alterations showed increased axial diffusivity (AxD; p < 0.05) similar to what was observed in aMCI and AD patients (p < 0.05). In the shared WM impairment tracts, SCD patients had FA values between the NC group and the other two patient groups. In the NC and SCD groups, the AVLT-delayed recall score correlated with higher AxD (r=-0.333, p=0.045), MD (r=-0.351, p=0.03) and RD (r=-0.353, p=0.025). In both the aMCI and AD groups the diffusion parameters were highly correlated with cognitive scores. Our study suggests that SCD patients present with widespread WM changes, which may contribute to the early memory decline they experience. | |
dc.publisher | Impact Journals LLC | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | adult | |
dc.subject | aged | |
dc.subject | aging | |
dc.subject | Alzheimer disease | |
dc.subject | Article | |
dc.subject | axial diffusivity | |
dc.subject | brain degeneration | |
dc.subject | cognitive defect | |
dc.subject | controlled study | |
dc.subject | diffusion tensor imaging | |
dc.subject | female | |
dc.subject | fractional anisotropy | |
dc.subject | human | |
dc.subject | image analysis | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | mean diffusivity | |
dc.subject | memory disorder | |
dc.subject | mild cognitive impairment | |
dc.subject | neuropsychological test | |
dc.subject | nuclear magnetic resonance scanner | |
dc.subject | physical parameters | |
dc.subject | radial diffusivity | |
dc.subject | recall | |
dc.subject | white matter | |
dc.subject | anisotropy | |
dc.subject | cognitive defect | |
dc.subject | diagnostic imaging | |
dc.subject | diffusion tensor imaging | |
dc.subject | middle aged | |
dc.subject | pathology | |
dc.subject | procedures | |
dc.subject | psychology | |
dc.subject | white matter | |
dc.subject | Aged | |
dc.subject | Anisotropy | |
dc.subject | Cognitive Dysfunction | |
dc.subject | Diffusion Tensor Imaging | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Neuropsychological Tests | |
dc.subject | White Matter | |
dc.type | Article | |
dc.contributor.department | LIFE SCIENCES INSTITUTE | |
dc.description.doi | 10.18632/oncotarget.10091 | |
dc.description.sourcetitle | Oncotarget | |
dc.description.volume | 7 | |
dc.description.issue | 34 | |
dc.description.page | 54405-54414 | |
dc.published.state | published | |
Appears in Collections: | Elements Staff Publications |
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