Please use this identifier to cite or link to this item: https://doi.org/10.7554/eLife.03271
Title: Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module
Authors: Matos, J.L
Lau, O.S 
Hachez, C
Cruz-Ramírez, A
Scheres, B
Bergmann, D.C
Keywords: Arabidopsis protein
basic helix loop helix transcription factor
FAMA protein, Arabidopsis
protein binding
RBR1 protein, Arabidopsis
amino acid sequence
Arabidopsis
cell cycle
cell differentiation
cell lineage
cytology
gene expression regulation
genetics
growth, development and aging
metabolism
molecular genetics
plant stoma
protein tertiary structure
sequence alignment
Amino Acid Sequence
Arabidopsis
Arabidopsis Proteins
Basic Helix-Loop-Helix Transcription Factors
Cell Cycle
Cell Differentiation
Cell Lineage
Gene Expression Regulation, Developmental
Gene Expression Regulation, Plant
Molecular Sequence Data
Plant Stomata
Protein Binding
Protein Structure, Tertiary
Sequence Alignment
Issue Date: 2014
Citation: Matos, J.L, Lau, O.S, Hachez, C, Cruz-Ramírez, A, Scheres, B, Bergmann, D.C (2014). Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. eLife 3 (41913) : 1-15. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.03271
Rights: Attribution 4.0 International
Abstract: The presumed totipotency of plant cells leads to questions about how specific stem cell lineages and terminal fates could be established. In the Arabidopsis stomatal lineage, a transient self-renewing phase creates precursors that differentiate into one of two epidermal cell types, guard cells or pavement cells. We found that irreversible differentiation of guard cells involves RETINOBLASTOMA-RELATED (RBR) recruitment to regulatory regions of master regulators of stomatal initiation, facilitated through interaction with a terminal stomatal lineage transcription factor, FAMA. Disrupting physical interactions between FAMA and RBR preferentially reveals the role of RBR in enforcing fate commitment over its role in cell-cycle control in this developmental context. Analysis of the phenotypes linked to the modulation of FAMA and RBR sheds new light on the way iterative divisions and terminal differentiation are coordinately regulated in a plant stem-cell lineage. © Matos et al.
Source Title: eLife
URI: https://scholarbank.nus.edu.sg/handle/10635/180377
ISSN: 2050084X
DOI: 10.7554/eLife.03271
Rights: Attribution 4.0 International
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