Please use this identifier to cite or link to this item:
https://doi.org/10.7554/eLife.03271
Title: | Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module | Authors: | Matos, J.L Lau, O.S Hachez, C Cruz-Ramírez, A Scheres, B Bergmann, D.C |
Keywords: | Arabidopsis protein basic helix loop helix transcription factor FAMA protein, Arabidopsis protein binding RBR1 protein, Arabidopsis amino acid sequence Arabidopsis cell cycle cell differentiation cell lineage cytology gene expression regulation genetics growth, development and aging metabolism molecular genetics plant stoma protein tertiary structure sequence alignment Amino Acid Sequence Arabidopsis Arabidopsis Proteins Basic Helix-Loop-Helix Transcription Factors Cell Cycle Cell Differentiation Cell Lineage Gene Expression Regulation, Developmental Gene Expression Regulation, Plant Molecular Sequence Data Plant Stomata Protein Binding Protein Structure, Tertiary Sequence Alignment |
Issue Date: | 2014 | Citation: | Matos, J.L, Lau, O.S, Hachez, C, Cruz-Ramírez, A, Scheres, B, Bergmann, D.C (2014). Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. eLife 3 (41913) : 1-15. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.03271 | Rights: | Attribution 4.0 International | Abstract: | The presumed totipotency of plant cells leads to questions about how specific stem cell lineages and terminal fates could be established. In the Arabidopsis stomatal lineage, a transient self-renewing phase creates precursors that differentiate into one of two epidermal cell types, guard cells or pavement cells. We found that irreversible differentiation of guard cells involves RETINOBLASTOMA-RELATED (RBR) recruitment to regulatory regions of master regulators of stomatal initiation, facilitated through interaction with a terminal stomatal lineage transcription factor, FAMA. Disrupting physical interactions between FAMA and RBR preferentially reveals the role of RBR in enforcing fate commitment over its role in cell-cycle control in this developmental context. Analysis of the phenotypes linked to the modulation of FAMA and RBR sheds new light on the way iterative divisions and terminal differentiation are coordinately regulated in a plant stem-cell lineage. © Matos et al. | Source Title: | eLife | URI: | https://scholarbank.nus.edu.sg/handle/10635/180377 | ISSN: | 2050084X | DOI: | 10.7554/eLife.03271 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_7554_eLife_03271.pdf | 5.73 MB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License