Please use this identifier to cite or link to this item:
https://doi.org/10.7554/eLife.03271
DC Field | Value | |
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dc.title | Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module | |
dc.contributor.author | Matos, J.L | |
dc.contributor.author | Lau, O.S | |
dc.contributor.author | Hachez, C | |
dc.contributor.author | Cruz-Ramírez, A | |
dc.contributor.author | Scheres, B | |
dc.contributor.author | Bergmann, D.C | |
dc.date.accessioned | 2020-10-26T08:33:59Z | |
dc.date.available | 2020-10-26T08:33:59Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Matos, J.L, Lau, O.S, Hachez, C, Cruz-Ramírez, A, Scheres, B, Bergmann, D.C (2014). Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. eLife 3 (41913) : 1-15. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.03271 | |
dc.identifier.issn | 2050084X | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/180377 | |
dc.description.abstract | The presumed totipotency of plant cells leads to questions about how specific stem cell lineages and terminal fates could be established. In the Arabidopsis stomatal lineage, a transient self-renewing phase creates precursors that differentiate into one of two epidermal cell types, guard cells or pavement cells. We found that irreversible differentiation of guard cells involves RETINOBLASTOMA-RELATED (RBR) recruitment to regulatory regions of master regulators of stomatal initiation, facilitated through interaction with a terminal stomatal lineage transcription factor, FAMA. Disrupting physical interactions between FAMA and RBR preferentially reveals the role of RBR in enforcing fate commitment over its role in cell-cycle control in this developmental context. Analysis of the phenotypes linked to the modulation of FAMA and RBR sheds new light on the way iterative divisions and terminal differentiation are coordinately regulated in a plant stem-cell lineage. © Matos et al. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | Arabidopsis protein | |
dc.subject | basic helix loop helix transcription factor | |
dc.subject | FAMA protein, Arabidopsis | |
dc.subject | protein binding | |
dc.subject | RBR1 protein, Arabidopsis | |
dc.subject | amino acid sequence | |
dc.subject | Arabidopsis | |
dc.subject | cell cycle | |
dc.subject | cell differentiation | |
dc.subject | cell lineage | |
dc.subject | cytology | |
dc.subject | gene expression regulation | |
dc.subject | genetics | |
dc.subject | growth, development and aging | |
dc.subject | metabolism | |
dc.subject | molecular genetics | |
dc.subject | plant stoma | |
dc.subject | protein tertiary structure | |
dc.subject | sequence alignment | |
dc.subject | Amino Acid Sequence | |
dc.subject | Arabidopsis | |
dc.subject | Arabidopsis Proteins | |
dc.subject | Basic Helix-Loop-Helix Transcription Factors | |
dc.subject | Cell Cycle | |
dc.subject | Cell Differentiation | |
dc.subject | Cell Lineage | |
dc.subject | Gene Expression Regulation, Developmental | |
dc.subject | Gene Expression Regulation, Plant | |
dc.subject | Molecular Sequence Data | |
dc.subject | Plant Stomata | |
dc.subject | Protein Binding | |
dc.subject | Protein Structure, Tertiary | |
dc.subject | Sequence Alignment | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.description.doi | 10.7554/eLife.03271 | |
dc.description.sourcetitle | eLife | |
dc.description.volume | 3 | |
dc.description.issue | 41913 | |
dc.description.page | 1-15 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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