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https://doi.org/10.3390/polym7101504
Title: | Pegylated fluorescent nanoparticles from one-pot atom transfer radical polymerization and "click chemistry" | Authors: | Xu, L.Q Li, N.N Zhang, B Chen, J.C Kang, E.-T |
Keywords: | Biocompatibility Cell culture Fluorescence Free radical polymerization Free radical reactions Nanoparticles Polyethylene glycols Polymerization Styrene Synthesis (chemical) Cellular imaging Click chemistry Fluorescent nanoparticles One-pot synthesis Pegylated Atom transfer radical polymerization |
Issue Date: | 2015 | Citation: | Xu, L.Q, Li, N.N, Zhang, B, Chen, J.C, Kang, E.-T (2015). Pegylated fluorescent nanoparticles from one-pot atom transfer radical polymerization and "click chemistry". Polymers 7 (10) : 2119-2130. ScholarBank@NUS Repository. https://doi.org/10.3390/polym7101504 | Rights: | Attribution 4.0 International | Abstract: | The preparation of PEGylated fluorescent nanoparticles (NPs) based on atom transfer radical polymerization (ATRP) and "click chemistry" in one-pot synthesis is presented. First, poly(p-chloromethyl styrene-alt-N-propargylmaleimide) (P(CMS-alt-NPM)) copolymer was prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization. Subsequently, the azido-containing fluorene-based polymer, poly[(9,9-dihexylfluorene)-alt-(9,9-bis-(6-azidohexyl)fluorene)] (PFC6N3), was synthesized via Suzuki coupling polymerization, followed by azidation. Finally, the PEGylated fluorescent NPs were prepared via simultaneous intermolecular "click" cross-linking between P(CMS-alt-NPM) and PFC6N3 and the ATRP of poly(ethylene glycol) methyl ether methacrylate (PEGMMA) using P(CMS-alt-NPM) as the macroinitiator. The low cytotoxicity of the PEGylated fluorescent NPs was revealed by incubation with KB cells, a cell line derived from carcinoma of the nasopharynx, in an in vitro experiment. The biocompatible PEGylated fluorescent NPs were further used as a labeling agent for KB cells. © 2015 by the authors; licensee MDPI, Basel, Switzerland. | Source Title: | Polymers | URI: | https://scholarbank.nus.edu.sg/handle/10635/180364 | ISSN: | 20734360 | DOI: | 10.3390/polym7101504 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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