Please use this identifier to cite or link to this item: https://doi.org/10.1101/gr.171439.113
Title: The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes
Authors: Teh, A.L
Pan, H
Chen, L
Ong, M.-L
Dogra, S
Wong, J
MacIsaac, J.L
Mah, S.M
McEwen, L.M
Saw, S.-M 
Godfrey, K.M
Chong, Y.-S 
Kwek, K 
Kwoh, C.-K
Soh, S.-E 
Chong, M.F.F 
Barton, S
Karnani, N 
Cheong, C.Y
Buschdorf, J.P
Stünkel, W
Kobor, M.S
Meaney, M.J
Gluckman, P.D
Holbrook, J.D
Keywords: DNA
DNA methylome
unclassified drug
transcriptome
article
birth order
birth weight
body mass
CpG island
cross reaction
DNA methylation
DNA sequence
environmental factor
ethnicity
female
genetic code
genetic variability
genotype
gestational age
human
inheritance
major clinical study
male
maternal smoking
newborn
prenatal exposure
priority journal
puerperal depression
quantitative trait locus
single nucleotide polymorphism
uterus
biology
DNA methylation
environment
epigenetics
genetic epigenesis
genetic heterogeneity
genotype environment interaction
pregnancy
procedures
risk factor
Computational Biology
CpG Islands
DNA Methylation
Environment
Epigenesis, Genetic
Epigenomics
Female
Gene-Environment Interaction
Genetic Heterogeneity
Genotype
Humans
Infant, Newborn
Male
Polymorphism, Single Nucleotide
Pregnancy
Quantitative Trait Loci
Risk Factors
Transcriptome
Issue Date: 2014
Publisher: Cold Spring Harbor Laboratory Press
Citation: Teh, A.L, Pan, H, Chen, L, Ong, M.-L, Dogra, S, Wong, J, MacIsaac, J.L, Mah, S.M, McEwen, L.M, Saw, S.-M, Godfrey, K.M, Chong, Y.-S, Kwek, K, Kwoh, C.-K, Soh, S.-E, Chong, M.F.F, Barton, S, Karnani, N, Cheong, C.Y, Buschdorf, J.P, Stünkel, W, Kobor, M.S, Meaney, M.J, Gluckman, P.D, Holbrook, J.D (2014). The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes. Genome Research 24 (7) : 1064-1074. ScholarBank@NUS Repository. https://doi.org/10.1101/gr.171439.113
Rights: Attribution 4.0 International
Abstract: Integrating the genotype with epigenetic marks holds the promise of better understanding the biology that underlies the complex interactions of inherited and environmental components that define the developmental origins of a range of disorders. The quality of the in utero environment significantly influences health over the lifecourse. Epigenetics, and in particular DNA methylation marks, have been postulated as a mechanism for the enduring effects of the prenatal environment. Accordingly, neonate methylomes contain molecular memory of the individual in utero experience. However, interindividual variation in methylation can also be a consequence of DNA sequence polymorphisms that result in methylation quantitative trait loci (methQTLs) and, potentially, the interaction between fixed genetic variation and environmental influences. We surveyed the genotypes and DNA methylomes of 237 neonates and found 1423 punctuate regions of the methylome that were highly variable across individuals, termed variably methylated regions (VMRs), against a backdrop of homogeneity. MethQTLs were readily detected in neonatal methylomes, and genotype alone best explained ?25% of the VMRs. We found that the best explanation for 75% of VMRs was the interaction of genotype with different in utero environments, including maternal smoking, maternal depression,maternal BMI, infant birth weight, gestational age, and birth order. Our study sheds new light on the complex relationship between biological inheritance as represented by genotype and individual prenatal experience and suggests the importance of considering both fixed genetic variation and environmental factors in interpreting epigenetic variation. © 2014 Teh et al.
Source Title: Genome Research
URI: https://scholarbank.nus.edu.sg/handle/10635/180177
ISSN: 1088-9051
DOI: 10.1101/gr.171439.113
Rights: Attribution 4.0 International
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