Please use this identifier to cite or link to this item: https://doi.org/10.1101/gr.171439.113
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dc.titleThe effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes
dc.contributor.authorTeh, A.L
dc.contributor.authorPan, H
dc.contributor.authorChen, L
dc.contributor.authorOng, M.-L
dc.contributor.authorDogra, S
dc.contributor.authorWong, J
dc.contributor.authorMacIsaac, J.L
dc.contributor.authorMah, S.M
dc.contributor.authorMcEwen, L.M
dc.contributor.authorSaw, S.-M
dc.contributor.authorGodfrey, K.M
dc.contributor.authorChong, Y.-S
dc.contributor.authorKwek, K
dc.contributor.authorKwoh, C.-K
dc.contributor.authorSoh, S.-E
dc.contributor.authorChong, M.F.F
dc.contributor.authorBarton, S
dc.contributor.authorKarnani, N
dc.contributor.authorCheong, C.Y
dc.contributor.authorBuschdorf, J.P
dc.contributor.authorStünkel, W
dc.contributor.authorKobor, M.S
dc.contributor.authorMeaney, M.J
dc.contributor.authorGluckman, P.D
dc.contributor.authorHolbrook, J.D
dc.date.accessioned2020-10-26T07:22:42Z
dc.date.available2020-10-26T07:22:42Z
dc.date.issued2014
dc.identifier.citationTeh, A.L, Pan, H, Chen, L, Ong, M.-L, Dogra, S, Wong, J, MacIsaac, J.L, Mah, S.M, McEwen, L.M, Saw, S.-M, Godfrey, K.M, Chong, Y.-S, Kwek, K, Kwoh, C.-K, Soh, S.-E, Chong, M.F.F, Barton, S, Karnani, N, Cheong, C.Y, Buschdorf, J.P, Stünkel, W, Kobor, M.S, Meaney, M.J, Gluckman, P.D, Holbrook, J.D (2014). The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes. Genome Research 24 (7) : 1064-1074. ScholarBank@NUS Repository. https://doi.org/10.1101/gr.171439.113
dc.identifier.issn1088-9051
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/180177
dc.description.abstractIntegrating the genotype with epigenetic marks holds the promise of better understanding the biology that underlies the complex interactions of inherited and environmental components that define the developmental origins of a range of disorders. The quality of the in utero environment significantly influences health over the lifecourse. Epigenetics, and in particular DNA methylation marks, have been postulated as a mechanism for the enduring effects of the prenatal environment. Accordingly, neonate methylomes contain molecular memory of the individual in utero experience. However, interindividual variation in methylation can also be a consequence of DNA sequence polymorphisms that result in methylation quantitative trait loci (methQTLs) and, potentially, the interaction between fixed genetic variation and environmental influences. We surveyed the genotypes and DNA methylomes of 237 neonates and found 1423 punctuate regions of the methylome that were highly variable across individuals, termed variably methylated regions (VMRs), against a backdrop of homogeneity. MethQTLs were readily detected in neonatal methylomes, and genotype alone best explained ?25% of the VMRs. We found that the best explanation for 75% of VMRs was the interaction of genotype with different in utero environments, including maternal smoking, maternal depression,maternal BMI, infant birth weight, gestational age, and birth order. Our study sheds new light on the complex relationship between biological inheritance as represented by genotype and individual prenatal experience and suggests the importance of considering both fixed genetic variation and environmental factors in interpreting epigenetic variation. © 2014 Teh et al.
dc.publisherCold Spring Harbor Laboratory Press
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectDNA
dc.subjectDNA methylome
dc.subjectunclassified drug
dc.subjecttranscriptome
dc.subjectarticle
dc.subjectbirth order
dc.subjectbirth weight
dc.subjectbody mass
dc.subjectCpG island
dc.subjectcross reaction
dc.subjectDNA methylation
dc.subjectDNA sequence
dc.subjectenvironmental factor
dc.subjectethnicity
dc.subjectfemale
dc.subjectgenetic code
dc.subjectgenetic variability
dc.subjectgenotype
dc.subjectgestational age
dc.subjecthuman
dc.subjectinheritance
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmaternal smoking
dc.subjectnewborn
dc.subjectprenatal exposure
dc.subjectpriority journal
dc.subjectpuerperal depression
dc.subjectquantitative trait locus
dc.subjectsingle nucleotide polymorphism
dc.subjectuterus
dc.subjectbiology
dc.subjectDNA methylation
dc.subjectenvironment
dc.subjectepigenetics
dc.subjectgenetic epigenesis
dc.subjectgenetic heterogeneity
dc.subjectgenotype environment interaction
dc.subjectpregnancy
dc.subjectprocedures
dc.subjectrisk factor
dc.subjectComputational Biology
dc.subjectCpG Islands
dc.subjectDNA Methylation
dc.subjectEnvironment
dc.subjectEpigenesis, Genetic
dc.subjectEpigenomics
dc.subjectFemale
dc.subjectGene-Environment Interaction
dc.subjectGenetic Heterogeneity
dc.subjectGenotype
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectMale
dc.subjectPolymorphism, Single Nucleotide
dc.subjectPregnancy
dc.subjectQuantitative Trait Loci
dc.subjectRisk Factors
dc.subjectTranscriptome
dc.typeArticle
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.contributor.departmentDEPT OF OBSTETRICS & GYNAECOLOGY
dc.contributor.departmentDEPT OF PAEDIATRICS
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1101/gr.171439.113
dc.description.sourcetitleGenome Research
dc.description.volume24
dc.description.issue7
dc.description.page1064-1074
dc.published.statePublished
dc.grant.idNMRC/TCR/004-NUS/2008
dc.grant.idNMRC/TCR/012-NUHS/2014
dc.grant.fundingagencyNational Medical Research Council
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