Please use this identifier to cite or link to this item:
https://doi.org/10.1101/gr.171439.113
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dc.title | The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes | |
dc.contributor.author | Teh, A.L | |
dc.contributor.author | Pan, H | |
dc.contributor.author | Chen, L | |
dc.contributor.author | Ong, M.-L | |
dc.contributor.author | Dogra, S | |
dc.contributor.author | Wong, J | |
dc.contributor.author | MacIsaac, J.L | |
dc.contributor.author | Mah, S.M | |
dc.contributor.author | McEwen, L.M | |
dc.contributor.author | Saw, S.-M | |
dc.contributor.author | Godfrey, K.M | |
dc.contributor.author | Chong, Y.-S | |
dc.contributor.author | Kwek, K | |
dc.contributor.author | Kwoh, C.-K | |
dc.contributor.author | Soh, S.-E | |
dc.contributor.author | Chong, M.F.F | |
dc.contributor.author | Barton, S | |
dc.contributor.author | Karnani, N | |
dc.contributor.author | Cheong, C.Y | |
dc.contributor.author | Buschdorf, J.P | |
dc.contributor.author | Stünkel, W | |
dc.contributor.author | Kobor, M.S | |
dc.contributor.author | Meaney, M.J | |
dc.contributor.author | Gluckman, P.D | |
dc.contributor.author | Holbrook, J.D | |
dc.date.accessioned | 2020-10-26T07:22:42Z | |
dc.date.available | 2020-10-26T07:22:42Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Teh, A.L, Pan, H, Chen, L, Ong, M.-L, Dogra, S, Wong, J, MacIsaac, J.L, Mah, S.M, McEwen, L.M, Saw, S.-M, Godfrey, K.M, Chong, Y.-S, Kwek, K, Kwoh, C.-K, Soh, S.-E, Chong, M.F.F, Barton, S, Karnani, N, Cheong, C.Y, Buschdorf, J.P, Stünkel, W, Kobor, M.S, Meaney, M.J, Gluckman, P.D, Holbrook, J.D (2014). The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes. Genome Research 24 (7) : 1064-1074. ScholarBank@NUS Repository. https://doi.org/10.1101/gr.171439.113 | |
dc.identifier.issn | 1088-9051 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/180177 | |
dc.description.abstract | Integrating the genotype with epigenetic marks holds the promise of better understanding the biology that underlies the complex interactions of inherited and environmental components that define the developmental origins of a range of disorders. The quality of the in utero environment significantly influences health over the lifecourse. Epigenetics, and in particular DNA methylation marks, have been postulated as a mechanism for the enduring effects of the prenatal environment. Accordingly, neonate methylomes contain molecular memory of the individual in utero experience. However, interindividual variation in methylation can also be a consequence of DNA sequence polymorphisms that result in methylation quantitative trait loci (methQTLs) and, potentially, the interaction between fixed genetic variation and environmental influences. We surveyed the genotypes and DNA methylomes of 237 neonates and found 1423 punctuate regions of the methylome that were highly variable across individuals, termed variably methylated regions (VMRs), against a backdrop of homogeneity. MethQTLs were readily detected in neonatal methylomes, and genotype alone best explained ?25% of the VMRs. We found that the best explanation for 75% of VMRs was the interaction of genotype with different in utero environments, including maternal smoking, maternal depression,maternal BMI, infant birth weight, gestational age, and birth order. Our study sheds new light on the complex relationship between biological inheritance as represented by genotype and individual prenatal experience and suggests the importance of considering both fixed genetic variation and environmental factors in interpreting epigenetic variation. © 2014 Teh et al. | |
dc.publisher | Cold Spring Harbor Laboratory Press | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | DNA | |
dc.subject | DNA methylome | |
dc.subject | unclassified drug | |
dc.subject | transcriptome | |
dc.subject | article | |
dc.subject | birth order | |
dc.subject | birth weight | |
dc.subject | body mass | |
dc.subject | CpG island | |
dc.subject | cross reaction | |
dc.subject | DNA methylation | |
dc.subject | DNA sequence | |
dc.subject | environmental factor | |
dc.subject | ethnicity | |
dc.subject | female | |
dc.subject | genetic code | |
dc.subject | genetic variability | |
dc.subject | genotype | |
dc.subject | gestational age | |
dc.subject | human | |
dc.subject | inheritance | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | maternal smoking | |
dc.subject | newborn | |
dc.subject | prenatal exposure | |
dc.subject | priority journal | |
dc.subject | puerperal depression | |
dc.subject | quantitative trait locus | |
dc.subject | single nucleotide polymorphism | |
dc.subject | uterus | |
dc.subject | biology | |
dc.subject | DNA methylation | |
dc.subject | environment | |
dc.subject | epigenetics | |
dc.subject | genetic epigenesis | |
dc.subject | genetic heterogeneity | |
dc.subject | genotype environment interaction | |
dc.subject | pregnancy | |
dc.subject | procedures | |
dc.subject | risk factor | |
dc.subject | Computational Biology | |
dc.subject | CpG Islands | |
dc.subject | DNA Methylation | |
dc.subject | Environment | |
dc.subject | Epigenesis, Genetic | |
dc.subject | Epigenomics | |
dc.subject | Female | |
dc.subject | Gene-Environment Interaction | |
dc.subject | Genetic Heterogeneity | |
dc.subject | Genotype | |
dc.subject | Humans | |
dc.subject | Infant, Newborn | |
dc.subject | Male | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Pregnancy | |
dc.subject | Quantitative Trait Loci | |
dc.subject | Risk Factors | |
dc.subject | Transcriptome | |
dc.type | Article | |
dc.contributor.department | DEPT OF BIOCHEMISTRY | |
dc.contributor.department | DEPT OF OBSTETRICS & GYNAECOLOGY | |
dc.contributor.department | DEPT OF PAEDIATRICS | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.1101/gr.171439.113 | |
dc.description.sourcetitle | Genome Research | |
dc.description.volume | 24 | |
dc.description.issue | 7 | |
dc.description.page | 1064-1074 | |
dc.published.state | Published | |
dc.grant.id | NMRC/TCR/004-NUS/2008 | |
dc.grant.id | NMRC/TCR/012-NUHS/2014 | |
dc.grant.fundingagency | National Medical Research Council | |
Appears in Collections: | Staff Publications Elements |
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