Please use this identifier to cite or link to this item: https://doi.org/10.1242/dev.074666
Title: Switching on cilia: Transcriptional networks regulating ciliogenesis
Authors: Choksi, S.P
Lauter, G
Swoboda, P
Roy, S 
Keywords: fibrocystin
forkhead transcription factor
hepatocyte nuclear factor 1beta
hormone receptor
kinesin 2
protein Myb
regulatory factor 1
regulatory factor 2
regulatory factor 3
regulatory factor 4
transcription factor
transcription factor FoxJ1
transcription factor Sox5
unclassified drug
biogenesis
Caenorhabditis elegans
cell differentiation
cell fate
cell lineage
ciliary motility
ciliated epithelium
ciliogenesis
DNA binding
DNA library
Drosophila melanogaster
ependyma cell
eukaryotic flagellum
fluid transport
gene control
gene expression
gene function
genetic conservation
human
mechanoreceptor
microtubule
mitosis
nonhuman
priority journal
protein domain
review
Saccharomyces cerevisiae
signal transduction
transactivation
transcription initiation
transcription regulation
Cilia
Ciliogenesis
FOXJ1
Motile cilia
RFX
Transcriptional regulation
Animals
Caenorhabditis elegans Proteins
Cilia
DNA-Binding Proteins
Forkhead Transcription Factors
Gene Expression Regulation, Developmental
Gene Regulatory Networks
Humans
Transcription Factors
Transcription, Genetic
Issue Date: 2014
Publisher: Company of Biologists Ltd
Citation: Choksi, S.P, Lauter, G, Swoboda, P, Roy, S (2014). Switching on cilia: Transcriptional networks regulating ciliogenesis. Development (Cambridge) 141 (7) : 1427-1441. ScholarBank@NUS Repository. https://doi.org/10.1242/dev.074666
Rights: Attribution 4.0 International
Abstract: Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory hubs for a variety of signal transduction pathways. Despite having a conserved basic morphology, cilia vary extensively in their shapes and sizes, ultrastructural details, numbers per cell, motility patterns and sensory capabilities. Emerging evidence indicates that this diversity, which is intimately linked to the different functions that cilia perform, is in large part programmed at the transcriptional level. Here, we review our understanding of the transcriptional control of ciliary biogenesis, highlighting the activities of FOXJ1 and the RFX family of transcriptional regulators. In addition, we examine how a number of signaling pathways, and lineage and cell fate determinants can induce and modulate ciliogenic programs to bring about the differentiation of distinct cilia types. © 2014. Published by The Company of Biologists Ltd.
Source Title: Development (Cambridge)
URI: https://scholarbank.nus.edu.sg/handle/10635/180145
ISSN: 0950-1991
DOI: 10.1242/dev.074666
Rights: Attribution 4.0 International
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