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Title: Novel H7N2 and H5N6 avian influenza A viruses in sentinel chickens: A sentinel chicken surveillance study
Authors: Zhao, T
Qian, Y.-H
Chen, S.-H
Wang, G.-L
Wu, M.-N
Huang, Y
Ma, G.-Y
Fang, L.-Q
Gray, G.C 
Lu, B
Tong, Y.-G
Ma, M.-J
Cao, W.-C
Keywords: amino acid
protein M2
antiviral resistance
avian influenza virus
gene mutation
genetic reassortment
Influenza A virus (H5N1)
Influenza A virus (H5N6)
Influenza A virus (H7N2)
Influenza A virus (H7N9)
Influenza A virus (H9N2)
mixed infection
real time polymerase chain reaction
sentinel species
sequence analysis
virus isolation
virus transmission
Issue Date: 2016
Citation: Zhao, T, Qian, Y.-H, Chen, S.-H, Wang, G.-L, Wu, M.-N, Huang, Y, Ma, G.-Y, Fang, L.-Q, Gray, G.C, Lu, B, Tong, Y.-G, Ma, M.-J, Cao, W.-C (2016). Novel H7N2 and H5N6 avian influenza A viruses in sentinel chickens: A sentinel chicken surveillance study. Frontiers in Microbiology 7 (NOV) : 1766. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: In 2014, a sentinel chicken surveillance for avian influenza viruses was conducted in aquatic bird habitat near Wuxi City, Jiangsu Province, China. Two H7N2, one H5N6, and two H9N2 viruses were isolated. Sequence analysis revealed that the H7N2 virus is a novel reassortant of H7N9 and H9N2 viruses and H5N6 virus is a reassortant of H5N1 clade 2.3.4 and H6N6 viruses. Substitutions V186 and L226 (H3 numbering) in the hemagglutinin (HA) gene protein was found in two H7N2 viruses but not in the H5N6 virus. Two A138 and A160 mutations were identified in the HA gene protein of all three viruses but a P128 mutation was only observed in the H5N6 virus. A deletion of 3 and 11 amino acids in the neuraminidase stalk region was found in two H7N2 and H5N6 viruses, respectively. Moreover, a mutation of N31 in M2 protein was observed in both two H7N2 viruses. High similarity of these isolated viruses to viruses previously identified among poultry and humans, suggests that peridomestic aquatic birds may play a role in sustaining novel virus transmission. Therefore, continued surveillance is needed to monitor these avian influenza viruses in wild bird and domestic poultry that may pose a threat to poultry and human health. © 2016 Zhao, Qian, Chen, Wang, Wu, Huang, Ma, Fang, Gray, Lu, Tong, Ma and Cao.
Source Title: Frontiers in Microbiology
ISSN: 1664302X
DOI: 10.3389/fmicb.2016.01766
Rights: Attribution 4.0 International
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