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https://doi.org/10.1038/ncomms13738
| Title: | Heritability of the shape of subcortical brain structures in the general population | Authors: | Roshchupkin, G.V Gutman, B.A Vernooij, M.W Jahanshad, N Martin, N.G Hofman, A McMahon, K.L Van Der Lee, S.J Van Duijn, C.M De Zubicaray, G.I Uitterlinden, A.G Wright, M.J Niessen, W.J Thompson, P.M Ikram, M.A Adams, H.H.H |
Keywords: | anatomy body shape brain complexity genetic analysis genotype heritability individual variation adult aged amygdala genotype globus pallidus heritability hippocampus human major clinical study nuclear magnetic resonance imaging nucleus accumbens population putamen reliability skull thalamus anatomy and histology brain caudate nucleus diagnostic imaging dizygotic twins female genetics male middle aged monozygotic twins organ size physiology reproducibility thalamus very elderly young adult Adult Aged Aged, 80 and over Amygdala Brain Caudate Nucleus Female Genotype Globus Pallidus Hippocampus Humans Magnetic Resonance Imaging Male Middle Aged Nucleus Accumbens Organ Size Putamen Reproducibility of Results Thalamus Twins, Dizygotic Twins, Monozygotic Young Adult |
Issue Date: | 2016 | Publisher: | Nature Publishing Group | Citation: | Roshchupkin, G.V, Gutman, B.A, Vernooij, M.W, Jahanshad, N, Martin, N.G, Hofman, A, McMahon, K.L, Van Der Lee, S.J, Van Duijn, C.M, De Zubicaray, G.I, Uitterlinden, A.G, Wright, M.J, Niessen, W.J, Thompson, P.M, Ikram, M.A, Adams, H.H.H (2016). Heritability of the shape of subcortical brain structures in the general population. Nature Communications 7 : 13738. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms13738 | Rights: | Attribution 4.0 International | Abstract: | The volumes of subcortical brain structures are highly heritable, but genetic underpinnings of their shape remain relatively obscure. Here we determine the relative contribution of genetic factors to individual variation in the shape of seven bilateral subcortical structures: the nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen and thalamus. In 3,686 unrelated individuals aged between 45 and 98 years, brain magnetic resonance imaging and genotyping was performed. The maximal heritability of shape varies from 32.7 to 53.3% across the subcortical structures. Genetic contributions to shape extend beyond influences on intracranial volume and the gross volume of the respective structure. The regional variance in heritability was related to the reliability of the measurements, but could not be accounted for by technical factors only. These findings could be replicated in an independent sample of 1,040 twins. Differences in genetic contributions within a single region reveal the value of refined brain maps to appreciate the genetic complexity of brain structures. © 2016 The Author(s). | Source Title: | Nature Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/179776 | ISSN: | 2041-1723 | DOI: | 10.1038/ncomms13738 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Elements Staff Publications |
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