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Please use this identifier to cite or link to this item: https://doi.org/10.1038/ncomms13738
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dc.titleHeritability of the shape of subcortical brain structures in the general population
dc.contributor.authorRoshchupkin, G.V
dc.contributor.authorGutman, B.A
dc.contributor.authorVernooij, M.W
dc.contributor.authorJahanshad, N
dc.contributor.authorMartin, N.G
dc.contributor.authorHofman, A
dc.contributor.authorMcMahon, K.L
dc.contributor.authorVan Der Lee, S.J
dc.contributor.authorVan Duijn, C.M
dc.contributor.authorDe Zubicaray, G.I
dc.contributor.authorUitterlinden, A.G
dc.contributor.authorWright, M.J
dc.contributor.authorNiessen, W.J
dc.contributor.authorThompson, P.M
dc.contributor.authorIkram, M.A
dc.contributor.authorAdams, H.H.H
dc.date.accessioned2020-10-26T03:04:05Z
dc.date.available2020-10-26T03:04:05Z
dc.date.issued2016
dc.identifier.citationRoshchupkin, G.V, Gutman, B.A, Vernooij, M.W, Jahanshad, N, Martin, N.G, Hofman, A, McMahon, K.L, Van Der Lee, S.J, Van Duijn, C.M, De Zubicaray, G.I, Uitterlinden, A.G, Wright, M.J, Niessen, W.J, Thompson, P.M, Ikram, M.A, Adams, H.H.H (2016). Heritability of the shape of subcortical brain structures in the general population. Nature Communications 7 : 13738. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms13738
dc.identifier.issn2041-1723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/179776
dc.description.abstractThe volumes of subcortical brain structures are highly heritable, but genetic underpinnings of their shape remain relatively obscure. Here we determine the relative contribution of genetic factors to individual variation in the shape of seven bilateral subcortical structures: the nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen and thalamus. In 3,686 unrelated individuals aged between 45 and 98 years, brain magnetic resonance imaging and genotyping was performed. The maximal heritability of shape varies from 32.7 to 53.3% across the subcortical structures. Genetic contributions to shape extend beyond influences on intracranial volume and the gross volume of the respective structure. The regional variance in heritability was related to the reliability of the measurements, but could not be accounted for by technical factors only. These findings could be replicated in an independent sample of 1,040 twins. Differences in genetic contributions within a single region reveal the value of refined brain maps to appreciate the genetic complexity of brain structures. © 2016 The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectanatomy
dc.subjectbody shape
dc.subjectbrain
dc.subjectcomplexity
dc.subjectgenetic analysis
dc.subjectgenotype
dc.subjectheritability
dc.subjectindividual variation
dc.subjectadult
dc.subjectaged
dc.subjectamygdala
dc.subjectgenotype
dc.subjectglobus pallidus
dc.subjectheritability
dc.subjecthippocampus
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectnuclear magnetic resonance imaging
dc.subjectnucleus accumbens
dc.subjectpopulation
dc.subjectputamen
dc.subjectreliability
dc.subjectskull
dc.subjectthalamus
dc.subjectanatomy and histology
dc.subjectbrain
dc.subjectcaudate nucleus
dc.subjectdiagnostic imaging
dc.subjectdizygotic twins
dc.subjectfemale
dc.subjectgenetics
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmonozygotic twins
dc.subjectorgan size
dc.subjectphysiology
dc.subjectreproducibility
dc.subjectthalamus
dc.subjectvery elderly
dc.subjectyoung adult
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAmygdala
dc.subjectBrain
dc.subjectCaudate Nucleus
dc.subjectFemale
dc.subjectGenotype
dc.subjectGlobus Pallidus
dc.subjectHippocampus
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNucleus Accumbens
dc.subjectOrgan Size
dc.subjectPutamen
dc.subjectReproducibility of Results
dc.subjectThalamus
dc.subjectTwins, Dizygotic
dc.subjectTwins, Monozygotic
dc.subjectYoung Adult
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/ncomms13738
dc.description.sourcetitleNature Communications
dc.description.volume7
dc.description.page13738
dc.published.statepublished
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