Please use this identifier to cite or link to this item: https://doi.org/10.1038/bcj.2017.74
Title: Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish
Authors: Lu, J.-W 
Hsieh, M.-S
Hou, H.-A
Chen, C.-Y
Tien, H.-F
Lin, L.-I
Keywords: CD135 antigen
messenger RNA
nucleophosmin
transcription factor Sox4
transcription factor Sox
tumor protein
zebrafish protein
acute myeloid leukemia
adult
animal experiment
animal model
animal tissue
Article
bone marrow cell
cancer patient
cancer prognosis
cell dedifferentiation
cell infiltration
controlled study
de novo acute myeloid leukemia
disease free survival
embryo
follow up
human
immunocytochemistry
in situ hybridization
induction chemotherapy
karyotype
karyotyping
kidney structure
leukemogenesis
leukocyte count
major clinical study
microscopy
myeloid progenitor cell
myelopoiesis
nonhuman
overall survival
patient
polymerase chain reaction
protein expression
quantitative analysis
remission
reverse transcription polymerase chain reaction
tissue section
zebra fish
acute myeloid leukemia
animal
biosynthesis
gene expression regulation
genetics
metabolism
myelopoiesis
pathology
transgenic animal
Animals
Animals, Genetically Modified
Gene Expression Regulation, Neoplastic
Leukemia, Myeloid, Acute
Myelopoiesis
Neoplasm Proteins
SOXC Transcription Factors
Zebrafish
Zebrafish Proteins
Issue Date: 2017
Publisher: Nature Publishing Group
Citation: Lu, J.-W, Hsieh, M.-S, Hou, H.-A, Chen, C.-Y, Tien, H.-F, Lin, L.-I (2017). Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish. Blood Cancer Journal 7 (8) : e593. ScholarBank@NUS Repository. https://doi.org/10.1038/bcj.2017.74
Rights: Attribution 4.0 International
Abstract: The SOX4 transcription factor is a key regulator of embryonic development, cell-fate decision, cellular differentiation and oncogenesis. Abnormal expression of SOX4 is related to malignant tumor transformation and cancer metastasis. However, no reports are available regarding the clinical significance of SOX4 in acute myeloid leukemia (AML) and the role of SOX4 in leukemogenesis. In the current study, we found that AML patients with low bone marrow (BM) SOX4 expression had higher remission rates and longer overall survival than those with high SOX4 expression, regardless of age, white blood cell count at diagnosis, karyotype profile and NPM1/FLT3-ITD status. To elucidate the role of SOX4 in leukemogenesis, we generated a transgenic zebrafish model that overexpressed human SOX4 in the myeloid lineage Tg(spi1-SOX4-EGFP). These transgenic zebrafish showed, at 5 months of age, increased myelopoiesis with dedifferentiation in kidney marrow. At 9 months of age, their kidney structure was significantly effaced and distorted by increased infiltration of myeloid progenitor cells. These results suggest that SOX4 is not only an independent prognostic factor of AML, but also an important molecular factor in leukemogenesis. © 2017 The Author(s).
Source Title: Blood Cancer Journal
URI: https://scholarbank.nus.edu.sg/handle/10635/179702
ISSN: 2044-5385
DOI: 10.1038/bcj.2017.74
Rights: Attribution 4.0 International
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