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https://doi.org/10.1099/vir.0.000155
Title: | Influenza A virus evolution and spatio-temporal dynamics in eurasian wild birds: A phylogenetic and phylogeographical study of whole-genome sequence data | Authors: | Lewis, N.S Verhagen, J.H Javakhishvili, Z Russell, C.A Lexmond, P Westgeest, K.B Bestebroer, T.M Halpin, R.A Lin, X Ransier, A Fedorova, N.B Stockwell, T.B Latorre-Margalef, N Olsen, B Smith, G Bahl, J Wentworth, D.E Waldenström, J Fouchier, R.A.M de Graaf, M |
Keywords: | genomic RNA Influenza virus hemagglutinin virus RNA allele Article Bayes theorem bird evolution gene sequence genetic reassortment genetic variability geographical variation (species) host Influenza A virus Influenza A virus (H5N1) innate immunity migrant bird nonhuman phylogenetic tree phylogeny priority journal species diversity virus genome animal avian influenza bird classification genetics Influenza A virus isolation and purification molecular evolution molecular genetics pathophysiology phylogeography physiology population migration virology wild animal Aves Influenza A virus Animal Migration Animals Animals, Wild Birds Evolution, Molecular Genome, Viral Influenza A virus Influenza in Birds Molecular Sequence Data Phylogeny Phylogeography RNA, Viral |
Issue Date: | 2015 | Publisher: | Microbiology Society | Citation: | Lewis, N.S, Verhagen, J.H, Javakhishvili, Z, Russell, C.A, Lexmond, P, Westgeest, K.B, Bestebroer, T.M, Halpin, R.A, Lin, X, Ransier, A, Fedorova, N.B, Stockwell, T.B, Latorre-Margalef, N, Olsen, B, Smith, G, Bahl, J, Wentworth, D.E, Waldenström, J, Fouchier, R.A.M, de Graaf, M (2015). Influenza A virus evolution and spatio-temporal dynamics in eurasian wild birds: A phylogenetic and phylogeographical study of whole-genome sequence data. Journal of General Virology 96 (8) : 2050-2060. ScholarBank@NUS Repository. https://doi.org/10.1099/vir.0.000155 | Rights: | Attribution 4.0 International | Abstract: | Low pathogenic avian influenza A viruses (IAVs) have a natural host reservoir in wild waterbirds and the potential to spread to other host species. Here, we investigated the evolutionary, spatial and temporal dynamics of avian IAVs in Eurasian wild birds. We used whole-genome sequences collected as part of an intensive long-term Eurasian wild bird surveillance study, and combined this genetic data with temporal and spatial information to explore the virus evolutionary dynamics. Frequent reassortment and co-circulating lineages were observed for all eight genomic RNA segments over time. There was no apparent species-specific effect on the diversity of the avian IAVs. There was a spatial and temporal relationship between the Eurasian sequences and significant viral migration of avian IAVs from West Eurasia towards Central Eurasia. The observed viral migration patterns differed between segments. Furthermore, we discuss the challenges faced when analysing these surveillance and sequence data, and the caveats to be borne in mind when drawing conclusions from the apparent results of such analyses. © 2015 The Authors. | Source Title: | Journal of General Virology | URI: | https://scholarbank.nus.edu.sg/handle/10635/179654 | ISSN: | 0022-1317 | DOI: | 10.1099/vir.0.000155 | Rights: | Attribution 4.0 International |
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