Please use this identifier to cite or link to this item: https://doi.org/10.1099/vir.0.000155
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dc.titleInfluenza A virus evolution and spatio-temporal dynamics in eurasian wild birds: A phylogenetic and phylogeographical study of whole-genome sequence data
dc.contributor.authorLewis, N.S
dc.contributor.authorVerhagen, J.H
dc.contributor.authorJavakhishvili, Z
dc.contributor.authorRussell, C.A
dc.contributor.authorLexmond, P
dc.contributor.authorWestgeest, K.B
dc.contributor.authorBestebroer, T.M
dc.contributor.authorHalpin, R.A
dc.contributor.authorLin, X
dc.contributor.authorRansier, A
dc.contributor.authorFedorova, N.B
dc.contributor.authorStockwell, T.B
dc.contributor.authorLatorre-Margalef, N
dc.contributor.authorOlsen, B
dc.contributor.authorSmith, G
dc.contributor.authorBahl, J
dc.contributor.authorWentworth, D.E
dc.contributor.authorWaldenström, J
dc.contributor.authorFouchier, R.A.M
dc.contributor.authorde Graaf, M
dc.date.accessioned2020-10-23T08:11:56Z
dc.date.available2020-10-23T08:11:56Z
dc.date.issued2015
dc.identifier.citationLewis, N.S, Verhagen, J.H, Javakhishvili, Z, Russell, C.A, Lexmond, P, Westgeest, K.B, Bestebroer, T.M, Halpin, R.A, Lin, X, Ransier, A, Fedorova, N.B, Stockwell, T.B, Latorre-Margalef, N, Olsen, B, Smith, G, Bahl, J, Wentworth, D.E, Waldenström, J, Fouchier, R.A.M, de Graaf, M (2015). Influenza A virus evolution and spatio-temporal dynamics in eurasian wild birds: A phylogenetic and phylogeographical study of whole-genome sequence data. Journal of General Virology 96 (8) : 2050-2060. ScholarBank@NUS Repository. https://doi.org/10.1099/vir.0.000155
dc.identifier.issn0022-1317
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/179654
dc.description.abstractLow pathogenic avian influenza A viruses (IAVs) have a natural host reservoir in wild waterbirds and the potential to spread to other host species. Here, we investigated the evolutionary, spatial and temporal dynamics of avian IAVs in Eurasian wild birds. We used whole-genome sequences collected as part of an intensive long-term Eurasian wild bird surveillance study, and combined this genetic data with temporal and spatial information to explore the virus evolutionary dynamics. Frequent reassortment and co-circulating lineages were observed for all eight genomic RNA segments over time. There was no apparent species-specific effect on the diversity of the avian IAVs. There was a spatial and temporal relationship between the Eurasian sequences and significant viral migration of avian IAVs from West Eurasia towards Central Eurasia. The observed viral migration patterns differed between segments. Furthermore, we discuss the challenges faced when analysing these surveillance and sequence data, and the caveats to be borne in mind when drawing conclusions from the apparent results of such analyses. © 2015 The Authors.
dc.publisherMicrobiology Society
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectgenomic RNA
dc.subjectInfluenza virus hemagglutinin
dc.subjectvirus RNA
dc.subjectallele
dc.subjectArticle
dc.subjectBayes theorem
dc.subjectbird
dc.subjectevolution
dc.subjectgene sequence
dc.subjectgenetic reassortment
dc.subjectgenetic variability
dc.subjectgeographical variation (species)
dc.subjecthost
dc.subjectInfluenza A virus
dc.subjectInfluenza A virus (H5N1)
dc.subjectinnate immunity
dc.subjectmigrant bird
dc.subjectnonhuman
dc.subjectphylogenetic tree
dc.subjectphylogeny
dc.subjectpriority journal
dc.subjectspecies diversity
dc.subjectvirus genome
dc.subjectanimal
dc.subjectavian influenza
dc.subjectbird
dc.subjectclassification
dc.subjectgenetics
dc.subjectInfluenza A virus
dc.subjectisolation and purification
dc.subjectmolecular evolution
dc.subjectmolecular genetics
dc.subjectpathophysiology
dc.subjectphylogeography
dc.subjectphysiology
dc.subjectpopulation migration
dc.subjectvirology
dc.subjectwild animal
dc.subjectAves
dc.subjectInfluenza A virus
dc.subjectAnimal Migration
dc.subjectAnimals
dc.subjectAnimals, Wild
dc.subjectBirds
dc.subjectEvolution, Molecular
dc.subjectGenome, Viral
dc.subjectInfluenza A virus
dc.subjectInfluenza in Birds
dc.subjectMolecular Sequence Data
dc.subjectPhylogeny
dc.subjectPhylogeography
dc.subjectRNA, Viral
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1099/vir.0.000155
dc.description.sourcetitleJournal of General Virology
dc.description.volume96
dc.description.issue8
dc.description.page2050-2060
dc.published.statePublished
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