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https://doi.org/10.3390/molecules200815108
| Title: | Unconventional bifunctional Lewis-Brønsted acid activation mode in bicyclic guanidine-catalyzed conjugate addition reactions | Authors: | Cho, B Wong, M.W |
Keywords: | fused heterocyclic rings guanidine Lewis acid phenol derivative phthalimide derivative thiol derivative thiophenol catalysis chemical structure chemistry conformation organic chemistry procedures Bicyclo Compounds, Heterocyclic Catalysis Chemistry, Organic Guanidine Lewis Acids Models, Molecular Molecular Conformation Phenols Phthalimides Sulfhydryl Compounds |
Issue Date: | 2015 | Publisher: | MDPI AG | Citation: | Cho, B, Wong, M.W (2015). Unconventional bifunctional Lewis-Brønsted acid activation mode in bicyclic guanidine-catalyzed conjugate addition reactions. Molecules 20 (8) : 15108-15121. ScholarBank@NUS Repository. https://doi.org/10.3390/molecules200815108 | Rights: | Attribution 4.0 International | Abstract: | DFT calculations have demonstrated that the unconventional bifunctional Brønsted-Lewis acid activation mode is generally applicable to a range of nucleophilic conjugate additions catalyzed by bicyclic guanidine catalysts. It competes readily with the conventional bifunctional Brønsted acid mode of activation. The optimal pro-nucleophiles for this unconventional bifunctional activation are acidic substrates with low pK |
Source Title: | Molecules | URI: | https://scholarbank.nus.edu.sg/handle/10635/179653 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules200815108 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Staff Publications Elements |
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