Please use this identifier to cite or link to this item: https://doi.org/10.1038/onc.2015.497
Title: Distinct routes to metastasis: Plasticity-dependent and plasticity-independent pathways
Authors: Somarelli, J.A
Schaeffer, D
Marengo, M.S
Bepler, T
Rouse, D
Ware, K.E
Hish, A.J
Zhao, Y
Buckley, A.F
Epstein, J.I
Armstrong, A.J
Virshup, D.M 
Garcia-Blanco, M.A
Keywords: animal cell
animal experiment
animal tissue
Article
cancer cell line
cancer model
carcinosarcoma
cell killing
cell plasticity
controlled study
epithelial mesenchymal transition
histopathology
human
human cell
in vivo study
major clinical study
metastasis
nonhuman
primary tumor
priority journal
prostate carcinoma
rat
transcription regulation
tumor growth
animal
Bagg albino mouse
cell proliferation
female
mouse
neoplasm
pathology
Animals
Cell Proliferation
Epithelial-Mesenchymal Transition
Female
Humans
Mice
Mice, Inbred BALB C
Neoplasm Metastasis
Neoplasms
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: Somarelli, J.A, Schaeffer, D, Marengo, M.S, Bepler, T, Rouse, D, Ware, K.E, Hish, A.J, Zhao, Y, Buckley, A.F, Epstein, J.I, Armstrong, A.J, Virshup, D.M, Garcia-Blanco, M.A (2016). Distinct routes to metastasis: Plasticity-dependent and plasticity-independent pathways. Oncogene 35 (33) : 4302-4311. ScholarBank@NUS Repository. https://doi.org/10.1038/onc.2015.497
Rights: Attribution 4.0 International
Abstract: The cascade that culminates in macrometastases is thought to be mediated by phenotypic plasticity, including epithelial-mesenchymal and mesenchymal-epithelial transitions (EMT and MET). Although there is substantial support for the role of EMT in driving cancer cell invasion and dissemination, much less is known about the importance of MET in the later steps of metastatic colonization. We created novel reporters, which integrate transcriptional and post-transcriptional regulation, to test whether MET is required for metastasis in multiple in vivo cancer models. In a model of carcinosarcoma, metastasis occurred via an MET-dependent pathway; however, in two prostate carcinoma models, metastatic colonization was MET independent. Our results provide evidence for both MET-dependent and MET-independent metastatic pathways. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Source Title: Oncogene
URI: https://scholarbank.nus.edu.sg/handle/10635/179294
ISSN: 0950-9232
DOI: 10.1038/onc.2015.497
Rights: Attribution 4.0 International
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