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Title: | ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study | Authors: | de Vries, P.S van Herpt, T.T.W Ligthart, S Hofman, A Ikram, M.A van Hoek, M Sijbrands, E.J.G Franco, O.H de Maat, M.P.M Leebeek, F.W.G Dehghan, A |
Keywords: | anticoagulant agent antihypertensive agent glucose insulin oral antidiabetic agent von Willebrand factor von Willebrand factor cleaving proteinase ADAMTS13 protein, human glucose blood level insulin von Willebrand factor von Willebrand factor cleaving proteinase aged Article cohort analysis diagnostic test accuracy study diet restriction disease association enzyme activity female glucose blood level human impaired glucose tolerance incidence incidental finding insulin treatment major clinical study male non insulin dependent diabetes mellitus population research priority journal prospective study risk factor blood Diabetes Mellitus, Type 2 genetics metabolism middle aged proportional hazards model ADAMTS13 Protein Aged Blood Glucose Diabetes Mellitus, Type 2 Fasting Female Humans Insulin Male Middle Aged Proportional Hazards Models Prospective Studies Risk Factors von Willebrand Factor |
Issue Date: | 2017 | Publisher: | Springer Verlag | Citation: | de Vries, P.S, van Herpt, T.T.W, Ligthart, S, Hofman, A, Ikram, M.A, van Hoek, M, Sijbrands, E.J.G, Franco, O.H, de Maat, M.P.M, Leebeek, F.W.G, Dehghan, A (2017). ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study. Diabetologia 60 (2) : 280-286. ScholarBank@NUS Repository. https://doi.org/10.1007/s00125-016-4139-5 | Rights: | Attribution 4.0 International | Abstract: | Aims/hypothesis: ADAMTS13 is a protease that breaks down von Willebrand factor (VWF) multimers into smaller, less active particles. VWF has been associated with an increased risk of incident type 2 diabetes mellitus. Here, we determine whether ADAMTS13 activity and VWF antigen are associated with incident diabetes. Methods: This study included 5176 participants from the Rotterdam Study, a prospective population-based cohort study. Participants were free of diabetes at baseline and followed up for more than 20 years. Cox proportional hazards models were used to examine the association of ADAMTS13 activity and VWF antigen with incident diabetes. Results: ADAMTS13 activity was associated with an increased risk of incident diabetes (HR 1.17 [95% CI 1.08, 1.27]) after adjustment for known risk factors and VWF antigen levels. Although ADAMTS13 activity was positively associated with fasting glucose and insulin, the association with incident diabetes did not change when we adjusted for these covariates. ADAMTS13 activity was also associated with incident prediabetes (defined on the basis of both fasting and non-fasting blood glucose) after adjustment for known risk factors (HR 1.11 [95% CI 1.03, 1.19]), while the VWF antigen level was not. VWF antigen was associated with incident diabetes, but this association was attenuated after adjustment for known risk factors. Conclusions/interpretation: ADAMTS13 activity appears to be an independent risk factor for incident prediabetes and type 2 diabetes. As the association between ADAMTS13 and diabetes did not appear to be explained by its cleavage of VWF, ADAMTS13 may have an independent role in the development of diabetes. © 2016, The Author(s). | Source Title: | Diabetologia | URI: | https://scholarbank.nus.edu.sg/handle/10635/179245 | ISSN: | 0012186X | DOI: | 10.1007/s00125-016-4139-5 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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