Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00125-016-4139-5
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dc.titleADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study
dc.contributor.authorde Vries, P.S
dc.contributor.authorvan Herpt, T.T.W
dc.contributor.authorLigthart, S
dc.contributor.authorHofman, A
dc.contributor.authorIkram, M.A
dc.contributor.authorvan Hoek, M
dc.contributor.authorSijbrands, E.J.G
dc.contributor.authorFranco, O.H
dc.contributor.authorde Maat, M.P.M
dc.contributor.authorLeebeek, F.W.G
dc.contributor.authorDehghan, A
dc.date.accessioned2020-10-23T02:35:51Z
dc.date.available2020-10-23T02:35:51Z
dc.date.issued2017
dc.identifier.citationde Vries, P.S, van Herpt, T.T.W, Ligthart, S, Hofman, A, Ikram, M.A, van Hoek, M, Sijbrands, E.J.G, Franco, O.H, de Maat, M.P.M, Leebeek, F.W.G, Dehghan, A (2017). ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study. Diabetologia 60 (2) : 280-286. ScholarBank@NUS Repository. https://doi.org/10.1007/s00125-016-4139-5
dc.identifier.issn0012186X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/179245
dc.description.abstractAims/hypothesis: ADAMTS13 is a protease that breaks down von Willebrand factor (VWF) multimers into smaller, less active particles. VWF has been associated with an increased risk of incident type 2 diabetes mellitus. Here, we determine whether ADAMTS13 activity and VWF antigen are associated with incident diabetes. Methods: This study included 5176 participants from the Rotterdam Study, a prospective population-based cohort study. Participants were free of diabetes at baseline and followed up for more than 20 years. Cox proportional hazards models were used to examine the association of ADAMTS13 activity and VWF antigen with incident diabetes. Results: ADAMTS13 activity was associated with an increased risk of incident diabetes (HR 1.17 [95% CI 1.08, 1.27]) after adjustment for known risk factors and VWF antigen levels. Although ADAMTS13 activity was positively associated with fasting glucose and insulin, the association with incident diabetes did not change when we adjusted for these covariates. ADAMTS13 activity was also associated with incident prediabetes (defined on the basis of both fasting and non-fasting blood glucose) after adjustment for known risk factors (HR 1.11 [95% CI 1.03, 1.19]), while the VWF antigen level was not. VWF antigen was associated with incident diabetes, but this association was attenuated after adjustment for known risk factors. Conclusions/interpretation: ADAMTS13 activity appears to be an independent risk factor for incident prediabetes and type 2 diabetes. As the association between ADAMTS13 and diabetes did not appear to be explained by its cleavage of VWF, ADAMTS13 may have an independent role in the development of diabetes. © 2016, The Author(s).
dc.publisherSpringer Verlag
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectanticoagulant agent
dc.subjectantihypertensive agent
dc.subjectglucose
dc.subjectinsulin
dc.subjectoral antidiabetic agent
dc.subjectvon Willebrand factor
dc.subjectvon Willebrand factor cleaving proteinase
dc.subjectADAMTS13 protein, human
dc.subjectglucose blood level
dc.subjectinsulin
dc.subjectvon Willebrand factor
dc.subjectvon Willebrand factor cleaving proteinase
dc.subjectaged
dc.subjectArticle
dc.subjectcohort analysis
dc.subjectdiagnostic test accuracy study
dc.subjectdiet restriction
dc.subjectdisease association
dc.subjectenzyme activity
dc.subjectfemale
dc.subjectglucose blood level
dc.subjecthuman
dc.subjectimpaired glucose tolerance
dc.subjectincidence
dc.subjectincidental finding
dc.subjectinsulin treatment
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectpopulation research
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectrisk factor
dc.subjectblood
dc.subjectDiabetes Mellitus, Type 2
dc.subjectgenetics
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectproportional hazards model
dc.subjectADAMTS13 Protein
dc.subjectAged
dc.subjectBlood Glucose
dc.subjectDiabetes Mellitus, Type 2
dc.subjectFasting
dc.subjectFemale
dc.subjectHumans
dc.subjectInsulin
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectProportional Hazards Models
dc.subjectProspective Studies
dc.subjectRisk Factors
dc.subjectvon Willebrand Factor
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1007/s00125-016-4139-5
dc.description.sourcetitleDiabetologia
dc.description.volume60
dc.description.issue2
dc.description.page280-286
dc.published.statePublished
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