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https://doi.org/10.1002/jmri.25638
Title: | Diagnostic performance of T1 and T2 mapping to detect intramyocardial hemorrhage in reperfused ST-segment elevation myocardial infarction (STEMI) patients | Authors: | Bulluck, H Rosmini, S Abdel-Gadir, A Bhuva, A.N Treibel, T.A Fontana, M Gonzalez-Lopez, E Ramlall, M Hamarneh, A Sirker, A Herrey, A.S Manisty, C Yellon, D.M Moon, J.C Hausenloy, D.J |
Keywords: | adult area under the curve Article bleeding cardiovascular magnetic resonance clinical article controlled study diagnostic accuracy diagnostic test accuracy study female heart disease human intramyocardial hemorrhage male percutaneous coronary intervention predictive value primary percutaneous coronary intervention priority journal prospective study quantitative analysis receiver operating characteristic sensitivity and specificity ST segment elevation myocardial infarction bleeding complication diagnostic imaging heart heart infarction heart muscle reperfusion middle aged nuclear magnetic resonance imaging procedures reproducibility Female Heart Hemorrhage Humans Magnetic Resonance Imaging Male Middle Aged Myocardial Infarction Myocardial Reperfusion Prospective Studies Reproducibility of Results Sensitivity and Specificity |
Issue Date: | 2017 | Publisher: | John Wiley and Sons Inc. | Citation: | Bulluck, H, Rosmini, S, Abdel-Gadir, A, Bhuva, A.N, Treibel, T.A, Fontana, M, Gonzalez-Lopez, E, Ramlall, M, Hamarneh, A, Sirker, A, Herrey, A.S, Manisty, C, Yellon, D.M, Moon, J.C, Hausenloy, D.J (2017). Diagnostic performance of T1 and T2 mapping to detect intramyocardial hemorrhage in reperfused ST-segment elevation myocardial infarction (STEMI) patients. Journal of Magnetic Resonance Imaging 46 (3) : 877-886. ScholarBank@NUS Repository. https://doi.org/10.1002/jmri.25638 | Rights: | Attribution 4.0 International | Abstract: | Purpose: To investigate the performance of T1 and T2 mapping to detect intramyocardial hemorrhage (IMH) in ST-segment elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention (PPCI). Materials and Methods: Fifty STEMI patients were prospectively recruited between August 2013 and July 2014 following informed consent. Forty-eight patients completed a 1.5T cardiac magnetic resonance imaging (MRI) with native T1, T2, and T2* maps at 4 ± 2 days. Receiver operating characteristic (ROC) analyses were performed to assess the performance of T1 and T2 to detect IMH. Results: The mean age was 59 ± 13 years old and 88% (24/48) were male. In all, 39 patients had interpretable T2* maps and 26/39 (67%) of the patients had IMH (T2* <20 msec on T2* maps). Both T1 and T2 values of the hypointense core within the area-at-risk (AAR) performed equally well to detect IMH (T1 maps AUC 0.86 [95% confidence interval [CI] 0.72–0.99] versus T2 maps AUC 0.86 [95% CI 0.74–0.99]; P = 0.94). Using the binary assessment of presence or absence of a hypointense core on the maps, the diagnostic performance of T1 and T2 remained equally good (T1 AUC 0.87 [95% CI 0.73–1.00] versus T2 AUC 0.85 [95% CI 0.71–0.99]; P = 0.90) with good sensitivity and specificity (T1: 88% and 85% and T2: 85% and 85%, respectively). Conclusion: The presence of a hypointense core on the T1 and T2 maps can detect IMH equally well and with good sensitivity and specificity in reperfused STEMI patients and could be used as an alternative when T2* images are not acquired or are not interpretable. Level of Evidence: 2. Technical Efficacy: Stage 2. J. MAGN. RESON. IMAGING 2017;46:877–886. © 2017 The Authors Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine | Source Title: | Journal of Magnetic Resonance Imaging | URI: | https://scholarbank.nus.edu.sg/handle/10635/179098 | ISSN: | 10531807 | DOI: | 10.1002/jmri.25638 | Rights: | Attribution 4.0 International |
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