Please use this identifier to cite or link to this item: https://doi.org/10.7554/eLife.18716
Title: Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding
Authors: Chen, N
Sugihara, H
Kim, J
Fu, Z
Barak, B
Sur, M
Feng, G
Han, W 
Keywords: glial fibrillary acidic protein
vimentin
glial fibrillary acidic protein
glial fibrillary astrocytic protein, mouse
adult
animal model
animal tissue
arcuate nucleus
Article
confocal microscopy
controlled study
electrophysiology
feeding behavior
food intake
glia cell
immunohistochemistry
mouse
nonhuman
protein expression
signal transduction
virus expression
animal
arcuate nucleus
biosynthesis
calcium signaling
cytology
glia
physiology
Animals
Arcuate Nucleus of Hypothalamus
Calcium Signaling
Feeding Behavior
Glial Fibrillary Acidic Protein
Mice
Neuroglia
Issue Date: 2016
Citation: Chen, N, Sugihara, H, Kim, J, Fu, Z, Barak, B, Sur, M, Feng, G, Han, W (2016). Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding. eLife 5 (42644) : e18716. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.18716
Rights: Attribution 4.0 International
Abstract: Multiple hypothalamic neuronal populations that regulate energy balance have been identified. Although hypothalamic glia exist in abundance and form intimate structural connections with neurons, their roles in energy homeostasis are less known. Here we show that selective Ca2+ activation of glia in the mouse arcuate nucleus (ARC) reversibly induces increased food intake while disruption of Ca2+ signaling pathway in ARC glia reduces food intake. The specific activation of ARC glia enhances the activity of agouti-related protein/neuropeptide Y (AgRP/NPY)-expressing neurons but induces no net response in pro-opiomelanocortin (POMC)-expressing neurons. ARC glial activation non-specifically depolarizes both AgRP/NPY and POMC neurons but a strong inhibitory input to POMC neurons balances the excitation. When AgRP/NPY neurons are inactivated, ARC glial activation fails to evoke any significant changes in food intake. Collectively, these results reveal an important role of ARC glia in the regulation of energy homeostasis through its interaction with distinct neuronal subtype-specific pathways. © Chen et al.
Source Title: eLife
URI: https://scholarbank.nus.edu.sg/handle/10635/178852
ISSN: 2050084X
DOI: 10.7554/eLife.18716
Rights: Attribution 4.0 International
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