Please use this identifier to cite or link to this item: https://doi.org/10.7554/eLife.18491
Title: Viral factors in influenza pandemic risk assessment
Authors: Lipsitch, M
Barclay, W
Raman, R
Russell, C.J
Belser, J.A
Cobey, S
Kasson, P.M
Lloyd-Smith, J.O
Maurer-Stroh, S 
Riley, S
Beauchemin, C.A
Bedford, T
Friedrich, T.C
Handel, A
Herfst, S
Murcia, P.R
Roche, B
Wilke, C.O
Russell, C.A
Keywords: cell protein
hemagglutinin
interferon
ribonucleoprotein
sialidase
Influenza virus hemagglutinin
RNA directed RNA polymerase
virulence factor
Article
bird
cytoplasm
ferret
gene mutation
gene sequence
genetic susceptibility
Influenza virus
nonhuman
pandemic influenza
pH
receptor binding
risk assessment
virus morphology
virus transmission
animal
epidemiological monitoring
genetics
human
Influenza A virus
Influenza, Human
metabolism
pandemic
pathogenicity
virology
Zoonoses
Animals
Epidemiological Monitoring
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Influenza A virus
Influenza, Human
Pandemics
Risk Assessment
RNA Replicase
Virulence Factors
Zoonoses
Issue Date: 2016
Citation: Lipsitch, M, Barclay, W, Raman, R, Russell, C.J, Belser, J.A, Cobey, S, Kasson, P.M, Lloyd-Smith, J.O, Maurer-Stroh, S, Riley, S, Beauchemin, C.A, Bedford, T, Friedrich, T.C, Handel, A, Herfst, S, Murcia, P.R, Roche, B, Wilke, C.O, Russell, C.A (2016). Viral factors in influenza pandemic risk assessment. eLife 5 (42675) : e18491. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.18491
Rights: Attribution 4.0 International
Abstract: The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans. To date, no pandemic emergence of a new influenza strain has been preceded by detection of a closely related precursor in an animal or human. Nonetheless, influenza surveillance efforts are expanding, prompting a need for tools to assess the pandemic risk posed by a detected virus. The goal would be to use genetic sequence and/or biological assays of viral traits to identify those non-human influenza viruses with the greatest risk of evolving into pandemic threats, and/or to understand drivers of such evolution, to prioritize pandemic prevention or response measures. We describe such efforts, identify progress and ongoing challenges, and discuss three specific traits of influenza viruses (hemagglutinin receptor binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency) that contribute to pandemic risk. © 2016, eLife Sciences Publications Ltd. All rights reserved.
Source Title: eLife
URI: https://scholarbank.nus.edu.sg/handle/10635/178845
ISSN: 2050084X
DOI: 10.7554/eLife.18491
Rights: Attribution 4.0 International
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