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https://doi.org/10.1038/srep37498
Title: | Female gender lost protective effect against disease progression in elderly patients with chronic hepatitis B | Authors: | You, H Kong, Y Hou, J Wei, L Zhang, Y Niu, J Han, T Ou, X Dou, X Shang, J Tang, H Xie, Q Ding, H Ren, H Xu, X Xie, W Liu, X Xu, Y Li, Y Li, J Chow, S.-C Zhuang, H Jia, J |
Keywords: | adult aged aging China chronic hepatitis B clinical trial complication cross-sectional study disease exacerbation female Hepatitis B virus human immunology innate immunity liver cirrhosis male middle aged multicenter study pathogenicity prevalence register sex factor virology Adult Aged Aging China Cross-Sectional Studies Disease Progression Female Hepatitis B virus Hepatitis B, Chronic Humans Immunity, Innate Liver Cirrhosis Male Middle Aged Prevalence Registries Sex Factors |
Issue Date: | 2016 | Citation: | You, H, Kong, Y, Hou, J, Wei, L, Zhang, Y, Niu, J, Han, T, Ou, X, Dou, X, Shang, J, Tang, H, Xie, Q, Ding, H, Ren, H, Xu, X, Xie, W, Liu, X, Xu, Y, Li, Y, Li, J, Chow, S.-C, Zhuang, H, Jia, J (2016). Female gender lost protective effect against disease progression in elderly patients with chronic hepatitis B. Scientific Reports 6 : 37498. ScholarBank@NUS Repository. https://doi.org/10.1038/srep37498 | Rights: | Attribution 4.0 International | Abstract: | Female gender and younger age are protective factors against disease progression in chronic hepatitis B (CHB). However, it is not clear whether the disease progression still remains slow in elderly females. This study investigated the interaction of female gender and older age on the development of cirrhosis in patients recorded in China Registry of Hepatitis B. A total of 17,809 CHB patients were enrolled in this multi-center cross-sectional study. The prevalence of cirrhosis in female CHB patients increased faster than that in male CHB patients over 50 years old. Multivariate analysis showed that the increase of adjusted ORs for developing cirrhosis in females started to accelerate after 50 years old: 11.19 (95% CI: 5.93-21.11) in women versus 14.75 (95% CI: 8.35-26.07) in men at ages of 50-59 years, 21.67 (95% CI: 11.05-42.47) versus 24.4 (95% CI: 13.00-45.80) at ages 60-69 years, and 18.78 (95% CI: 6.61-53.36) versus 12.09 (95% CI: 4.35-33.61) in those over 70 years. In conclusion, the protective effect of female gender against cirrhosis gradually lost with increasing age, therefore disease progression should be monitored more closely in elderly women with CHB. | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/178752 | ISSN: | 20452322 | DOI: | 10.1038/srep37498 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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