Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep37498
Title: Female gender lost protective effect against disease progression in elderly patients with chronic hepatitis B
Authors: You, H
Kong, Y
Hou, J
Wei, L
Zhang, Y
Niu, J
Han, T
Ou, X
Dou, X
Shang, J
Tang, H
Xie, Q
Ding, H
Ren, H
Xu, X
Xie, W
Liu, X
Xu, Y
Li, Y
Li, J
Chow, S.-C 
Zhuang, H
Jia, J
Keywords: adult
aged
aging
China
chronic hepatitis B
clinical trial
complication
cross-sectional study
disease exacerbation
female
Hepatitis B virus
human
immunology
innate immunity
liver cirrhosis
male
middle aged
multicenter study
pathogenicity
prevalence
register
sex factor
virology
Adult
Aged
Aging
China
Cross-Sectional Studies
Disease Progression
Female
Hepatitis B virus
Hepatitis B, Chronic
Humans
Immunity, Innate
Liver Cirrhosis
Male
Middle Aged
Prevalence
Registries
Sex Factors
Issue Date: 2016
Citation: You, H, Kong, Y, Hou, J, Wei, L, Zhang, Y, Niu, J, Han, T, Ou, X, Dou, X, Shang, J, Tang, H, Xie, Q, Ding, H, Ren, H, Xu, X, Xie, W, Liu, X, Xu, Y, Li, Y, Li, J, Chow, S.-C, Zhuang, H, Jia, J (2016). Female gender lost protective effect against disease progression in elderly patients with chronic hepatitis B. Scientific Reports 6 : 37498. ScholarBank@NUS Repository. https://doi.org/10.1038/srep37498
Rights: Attribution 4.0 International
Abstract: Female gender and younger age are protective factors against disease progression in chronic hepatitis B (CHB). However, it is not clear whether the disease progression still remains slow in elderly females. This study investigated the interaction of female gender and older age on the development of cirrhosis in patients recorded in China Registry of Hepatitis B. A total of 17,809 CHB patients were enrolled in this multi-center cross-sectional study. The prevalence of cirrhosis in female CHB patients increased faster than that in male CHB patients over 50 years old. Multivariate analysis showed that the increase of adjusted ORs for developing cirrhosis in females started to accelerate after 50 years old: 11.19 (95% CI: 5.93-21.11) in women versus 14.75 (95% CI: 8.35-26.07) in men at ages of 50-59 years, 21.67 (95% CI: 11.05-42.47) versus 24.4 (95% CI: 13.00-45.80) at ages 60-69 years, and 18.78 (95% CI: 6.61-53.36) versus 12.09 (95% CI: 4.35-33.61) in those over 70 years. In conclusion, the protective effect of female gender against cirrhosis gradually lost with increasing age, therefore disease progression should be monitored more closely in elderly women with CHB.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178752
ISSN: 20452322
DOI: 10.1038/srep37498
Rights: Attribution 4.0 International
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