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https://doi.org/10.12688/f1000research.10736.1
| Title: | Recent advances in acute promyelocytic leukaemia | Authors: | Ng, C.-H Chng, W.-J |
Keywords: | arsenic trioxide CD135 antigen retinoic acid tyrosine kinase receptor cancer classification cancer incidence cancer prognosis cancer recurrence cancer regression cell proliferation chromosome 15 chromosome 17 controlled study disease free survival event free survival fatality fusion gene gene mutation gene targeting human in vitro study in vivo study major clinical study myeloid progenitor cell overall survival promyelocytic leukemia reciprocal chromosome translocation Review risk factor |
Issue Date: | 2017 | Citation: | Ng, C.-H, Chng, W.-J (2017). Recent advances in acute promyelocytic leukaemia. F1000Research 6 : 1273. ScholarBank@NUS Repository. https://doi.org/10.12688/f1000research.10736.1 | Rights: | Attribution 4.0 International | Abstract: | Acute promyelocytic leukaemia (APML) is a subtype of leukaemia arising from a distinct reciprocal translocation involving chromosomes 15 and 17, which results in the PML-RARA fusion gene. Over the past three decades, APML has been transformed from a highly fatal disease to a highly curable one. This drastic improvement is because of the introduction of a new treatment strategy with all-trans retinoic acid and, more recently, arsenic trioxide. The revolutionary treatment of APML has also paved the way for a new cancer treatment, which is genetically targeted therapy. In this review, we look into this amazing journey of transformation and provide recent advances in the management of APML. © 2017 Ng CH and Chng WJ. | Source Title: | F1000Research | URI: | https://scholarbank.nus.edu.sg/handle/10635/178716 | ISSN: | 20461402 | DOI: | 10.12688/f1000research.10736.1 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Elements Staff Publications |
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