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Please use this identifier to cite or link to this item: https://doi.org/10.12688/f1000research.10736.1
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dc.titleRecent advances in acute promyelocytic leukaemia
dc.contributor.authorNg, C.-H
dc.contributor.authorChng, W.-J
dc.date.accessioned2020-10-21T08:05:40Z
dc.date.available2020-10-21T08:05:40Z
dc.date.issued2017
dc.identifier.citationNg, C.-H, Chng, W.-J (2017). Recent advances in acute promyelocytic leukaemia. F1000Research 6 : 1273. ScholarBank@NUS Repository. https://doi.org/10.12688/f1000research.10736.1
dc.identifier.issn20461402
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178716
dc.description.abstractAcute promyelocytic leukaemia (APML) is a subtype of leukaemia arising from a distinct reciprocal translocation involving chromosomes 15 and 17, which results in the PML-RARA fusion gene. Over the past three decades, APML has been transformed from a highly fatal disease to a highly curable one. This drastic improvement is because of the introduction of a new treatment strategy with all-trans retinoic acid and, more recently, arsenic trioxide. The revolutionary treatment of APML has also paved the way for a new cancer treatment, which is genetically targeted therapy. In this review, we look into this amazing journey of transformation and provide recent advances in the management of APML. © 2017 Ng CH and Chng WJ.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectarsenic trioxide
dc.subjectCD135 antigen
dc.subjectretinoic acid
dc.subjecttyrosine kinase receptor
dc.subjectcancer classification
dc.subjectcancer incidence
dc.subjectcancer prognosis
dc.subjectcancer recurrence
dc.subjectcancer regression
dc.subjectcell proliferation
dc.subjectchromosome 15
dc.subjectchromosome 17
dc.subjectcontrolled study
dc.subjectdisease free survival
dc.subjectevent free survival
dc.subjectfatality
dc.subjectfusion gene
dc.subjectgene mutation
dc.subjectgene targeting
dc.subjecthuman
dc.subjectin vitro study
dc.subjectin vivo study
dc.subjectmajor clinical study
dc.subjectmyeloid progenitor cell
dc.subjectoverall survival
dc.subjectpromyelocytic leukemia
dc.subjectreciprocal chromosome translocation
dc.subjectReview
dc.subjectrisk factor
dc.typeReview
dc.contributor.departmentMEDICINE
dc.description.doi10.12688/f1000research.10736.1
dc.description.sourcetitleF1000Research
dc.description.volume6
dc.description.page1273
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