Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-19321-1
Title: Ocular and clinical characteristics associated with the extent of posterior lamina cribrosa curve in normal tension glaucoma
Authors: Lee, S.H
Kim, T.-W
Lee, E.J
Girard, M.J.A 
Mari, J.M
Ritch, R
Keywords: adult
aged
cross-sectional study
female
human
intraocular pressure
low tension glaucoma
male
middle aged
nerve fiber
optic disk
optic nerve injury
optical coherence tomography
pathology
perimetry
physiology
procedures
visual acuity
visual field
Adult
Aged
Cross-Sectional Studies
Female
Humans
Intraocular Pressure
Low Tension Glaucoma
Male
Middle Aged
Nerve Fibers
Optic Disk
Optic Nerve Injuries
Tomography, Optical Coherence
Visual Acuity
Visual Field Tests
Visual Fields
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Lee, S.H, Kim, T.-W, Lee, E.J, Girard, M.J.A, Mari, J.M, Ritch, R (2018). Ocular and clinical characteristics associated with the extent of posterior lamina cribrosa curve in normal tension glaucoma. Scientific Reports 8 (1) : 961. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-19321-1
Rights: Attribution 4.0 International
Abstract: Although normal-tension glaucoma (NTG) is pathogenetically heterogenous, there have been few attempts to subclassify NTG patients according to the mechanism and anatomy of optic nerve damage. This cross-sectional study was performed to investigate differences in the clinical and ocular characteristics between NTG patient groups stratified according to the degree of posterior lamina cribrosa (LC) curve which was assessed by calculating LC curvature index (LCCI). A total of 101 eyes of 101 treatment naïve NTG patients were included. The optic nerve head was imaged using enhanced-depth-imaging spectral-domain optical coherence tomography in three horizontal B-scan images in each eye. The patients were divided into two groups based on the magnitude of LCCI using a cutoff of known upper 95 percentile value in healthy subjects: a steeply curved LC group (Group 1, 75 eyes, 74.3%) and a relatively flat LC group (Group 2, 26 eyes, 25.7%). NTG eyes with relatively flat LC had lower intraocular pressure, and were associated with greater parapapillary structural alternation and systemic risk factors. These data suggest that assessment of LC morphology may help clinicians seek additional risk factors and make inferences about the mechanism of optic nerve damage in individual patients. © 2018 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178525
ISSN: 2045-2322
DOI: 10.1038/s41598-018-19321-1
Rights: Attribution 4.0 International
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