Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-19321-1
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dc.titleOcular and clinical characteristics associated with the extent of posterior lamina cribrosa curve in normal tension glaucoma
dc.contributor.authorLee, S.H
dc.contributor.authorKim, T.-W
dc.contributor.authorLee, E.J
dc.contributor.authorGirard, M.J.A
dc.contributor.authorMari, J.M
dc.contributor.authorRitch, R
dc.date.accessioned2020-10-20T10:09:25Z
dc.date.available2020-10-20T10:09:25Z
dc.date.issued2018
dc.identifier.citationLee, S.H, Kim, T.-W, Lee, E.J, Girard, M.J.A, Mari, J.M, Ritch, R (2018). Ocular and clinical characteristics associated with the extent of posterior lamina cribrosa curve in normal tension glaucoma. Scientific Reports 8 (1) : 961. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-19321-1
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178525
dc.description.abstractAlthough normal-tension glaucoma (NTG) is pathogenetically heterogenous, there have been few attempts to subclassify NTG patients according to the mechanism and anatomy of optic nerve damage. This cross-sectional study was performed to investigate differences in the clinical and ocular characteristics between NTG patient groups stratified according to the degree of posterior lamina cribrosa (LC) curve which was assessed by calculating LC curvature index (LCCI). A total of 101 eyes of 101 treatment naïve NTG patients were included. The optic nerve head was imaged using enhanced-depth-imaging spectral-domain optical coherence tomography in three horizontal B-scan images in each eye. The patients were divided into two groups based on the magnitude of LCCI using a cutoff of known upper 95 percentile value in healthy subjects: a steeply curved LC group (Group 1, 75 eyes, 74.3%) and a relatively flat LC group (Group 2, 26 eyes, 25.7%). NTG eyes with relatively flat LC had lower intraocular pressure, and were associated with greater parapapillary structural alternation and systemic risk factors. These data suggest that assessment of LC morphology may help clinicians seek additional risk factors and make inferences about the mechanism of optic nerve damage in individual patients. © 2018 The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectadult
dc.subjectaged
dc.subjectcross-sectional study
dc.subjectfemale
dc.subjecthuman
dc.subjectintraocular pressure
dc.subjectlow tension glaucoma
dc.subjectmale
dc.subjectmiddle aged
dc.subjectnerve fiber
dc.subjectoptic disk
dc.subjectoptic nerve injury
dc.subjectoptical coherence tomography
dc.subjectpathology
dc.subjectperimetry
dc.subjectphysiology
dc.subjectprocedures
dc.subjectvisual acuity
dc.subjectvisual field
dc.subjectAdult
dc.subjectAged
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectIntraocular Pressure
dc.subjectLow Tension Glaucoma
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNerve Fibers
dc.subjectOptic Disk
dc.subjectOptic Nerve Injuries
dc.subjectTomography, Optical Coherence
dc.subjectVisual Acuity
dc.subjectVisual Field Tests
dc.subjectVisual Fields
dc.typeArticle
dc.contributor.departmentDEPT OF BIOMEDICAL ENGINEERING
dc.description.doi10.1038/s41598-018-19321-1
dc.description.sourcetitleScientific Reports
dc.description.volume8
dc.description.issue1
dc.description.page961
dc.published.statepublished
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