Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-20409-x
Title: Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle
Authors: Luo, X
Xue, L
Xu, H
Zhao, Q.-Y
Wang, Q
She, Y.-S
Zang, D.-A
Shen, J
Peng, Y.-B
Zhao, P
Yu, M.-F
Chen, W
Ma, L.-Q
Chen, S
Chen, S
Fu, X
Hu, S
Nie, X 
Shen, C
Zou, C
Qin, G
Dai, J
Ji, G
Su, Y
Hu, S
Chen, J
Liu, Q.-H
Keywords: acetylcholine
calcium
calcium channel L type
nifedipine
plant extract
quercetin
transient receptor potential channel C
animal
Bagg albino mouse
chemistry
drug effect
human
lung
male
metabolism
mouse
muscle contraction
Polygonum
smooth muscle
Acetylcholine
Animals
Calcium
Calcium Channels, L-Type
Humans
Lung
Male
Mice
Mice, Inbred BALB C
Muscle Contraction
Muscle, Smooth
Nifedipine
Plant Extracts
Polygonum
Quercetin
TRPC Cation Channels
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Luo, X, Xue, L, Xu, H, Zhao, Q.-Y, Wang, Q, She, Y.-S, Zang, D.-A, Shen, J, Peng, Y.-B, Zhao, P, Yu, M.-F, Chen, W, Ma, L.-Q, Chen, S, Chen, S, Fu, X, Hu, S, Nie, X, Shen, C, Zou, C, Qin, G, Dai, J, Ji, G, Su, Y, Hu, S, Chen, J, Liu, Q.-H (2018). Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle. Scientific Reports 8 (1) : 3114. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-20409-x
Rights: Attribution 4.0 International
Abstract: Because of the serious side effects of the currently used bronchodilators, new compounds with similar functions must be developed. We screened several herbs and found that Polygonum aviculare L. contains ingredients that inhibit the precontraction of mouse and human airway smooth muscle (ASM). High K+-induced precontraction in ASM was completely inhibited by nifedipine, a selective blocker of L-type voltage-dependent Ca2+ channels (LVDCCs). However, nifedipine only partially reduced the precontraction induced by acetylcholine chloride (ACH). Additionally, the ACH-induced precontraction was partly reduced by pyrazole-3 (Pyr3), a selective blocker of TRPC3 and stromal interaction molecule (STIM)/Orai channels. These channel-mediated currents were inhibited by the compounds present in P. aviculare extracts, suggesting that this inhibition was mediated by LVDCCs, TRPC3 and/or STIM/Orai channels. Moreover, these channel-mediated currents were inhibited by quercetin, which is present in P. aviculare extracts. Furthermore, quercetin inhibited ACH-induced precontraction in ASM. Overall, our data indicate that the ethyl acetate fraction of P. aviculare and quercetin can inhibit Ca2+-permeant LVDCCs, TRPC3 and STIM/Orai channels, which inhibits the precontraction of ASM. These findings suggest that P. aviculare could be used to develop new bronchodilators to treat obstructive lung diseases such as asthma and chronic obstructive pulmonary disease. © 2018 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178433
ISSN: 2045-2322
DOI: 10.1038/s41598-018-20409-x
Rights: Attribution 4.0 International
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