Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-20409-x
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dc.titlePolygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle
dc.contributor.authorLuo, X
dc.contributor.authorXue, L
dc.contributor.authorXu, H
dc.contributor.authorZhao, Q.-Y
dc.contributor.authorWang, Q
dc.contributor.authorShe, Y.-S
dc.contributor.authorZang, D.-A
dc.contributor.authorShen, J
dc.contributor.authorPeng, Y.-B
dc.contributor.authorZhao, P
dc.contributor.authorYu, M.-F
dc.contributor.authorChen, W
dc.contributor.authorMa, L.-Q
dc.contributor.authorChen, S
dc.contributor.authorChen, S
dc.contributor.authorFu, X
dc.contributor.authorHu, S
dc.contributor.authorNie, X
dc.contributor.authorShen, C
dc.contributor.authorZou, C
dc.contributor.authorQin, G
dc.contributor.authorDai, J
dc.contributor.authorJi, G
dc.contributor.authorSu, Y
dc.contributor.authorHu, S
dc.contributor.authorChen, J
dc.contributor.authorLiu, Q.-H
dc.date.accessioned2020-10-20T09:57:29Z
dc.date.available2020-10-20T09:57:29Z
dc.date.issued2018
dc.identifier.citationLuo, X, Xue, L, Xu, H, Zhao, Q.-Y, Wang, Q, She, Y.-S, Zang, D.-A, Shen, J, Peng, Y.-B, Zhao, P, Yu, M.-F, Chen, W, Ma, L.-Q, Chen, S, Chen, S, Fu, X, Hu, S, Nie, X, Shen, C, Zou, C, Qin, G, Dai, J, Ji, G, Su, Y, Hu, S, Chen, J, Liu, Q.-H (2018). Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle. Scientific Reports 8 (1) : 3114. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-20409-x
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178433
dc.description.abstractBecause of the serious side effects of the currently used bronchodilators, new compounds with similar functions must be developed. We screened several herbs and found that Polygonum aviculare L. contains ingredients that inhibit the precontraction of mouse and human airway smooth muscle (ASM). High K+-induced precontraction in ASM was completely inhibited by nifedipine, a selective blocker of L-type voltage-dependent Ca2+ channels (LVDCCs). However, nifedipine only partially reduced the precontraction induced by acetylcholine chloride (ACH). Additionally, the ACH-induced precontraction was partly reduced by pyrazole-3 (Pyr3), a selective blocker of TRPC3 and stromal interaction molecule (STIM)/Orai channels. These channel-mediated currents were inhibited by the compounds present in P. aviculare extracts, suggesting that this inhibition was mediated by LVDCCs, TRPC3 and/or STIM/Orai channels. Moreover, these channel-mediated currents were inhibited by quercetin, which is present in P. aviculare extracts. Furthermore, quercetin inhibited ACH-induced precontraction in ASM. Overall, our data indicate that the ethyl acetate fraction of P. aviculare and quercetin can inhibit Ca2+-permeant LVDCCs, TRPC3 and STIM/Orai channels, which inhibits the precontraction of ASM. These findings suggest that P. aviculare could be used to develop new bronchodilators to treat obstructive lung diseases such as asthma and chronic obstructive pulmonary disease. © 2018 The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectacetylcholine
dc.subjectcalcium
dc.subjectcalcium channel L type
dc.subjectnifedipine
dc.subjectplant extract
dc.subjectquercetin
dc.subjecttransient receptor potential channel C
dc.subjectanimal
dc.subjectBagg albino mouse
dc.subjectchemistry
dc.subjectdrug effect
dc.subjecthuman
dc.subjectlung
dc.subjectmale
dc.subjectmetabolism
dc.subjectmouse
dc.subjectmuscle contraction
dc.subjectPolygonum
dc.subjectsmooth muscle
dc.subjectAcetylcholine
dc.subjectAnimals
dc.subjectCalcium
dc.subjectCalcium Channels, L-Type
dc.subjectHumans
dc.subjectLung
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred BALB C
dc.subjectMuscle Contraction
dc.subjectMuscle, Smooth
dc.subjectNifedipine
dc.subjectPlant Extracts
dc.subjectPolygonum
dc.subjectQuercetin
dc.subjectTRPC Cation Channels
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1038/s41598-018-20409-x
dc.description.sourcetitleScientific Reports
dc.description.volume8
dc.description.issue1
dc.description.page3114
dc.published.statepublished
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