Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-018-03811-x
Title: Gene expression links functional networks across cortex and striatum
Authors: Anderson, K.M
Krienen, F.M
Choi, E.Y
Reinen, J.M
Yeo, B.T.T 
Holmes, A.J
Keywords: biological marker
chloride channel
parvalbumin
somatostatin
biological marker
chloride channel
parvalbumin
somatostatin
brain
chloride
enzyme
gene
gene expression
genetic marker
hominid
molecular analysis
nervous system
Article
brain cortex
brain region
corpus striatum
functional connectivity
functional magnetic resonance imaging
gene expression
genetic conservation
human
human tissue
limbic cortex
motor cortex
nerve cell network
nonhuman
nucleus accumbens
oligodendroglia
orbital cortex
primate
temporal cortex
ventromedial prefrontal cortex
adult
anatomy and histology
animal
autopsy
book
cytology
female
gene expression profiling
genetics
Macaca
male
metabolism
middle aged
nerve cell
nerve tract
prefrontal cortex
temporal lobe
Primates
Adult
Animals
Atlases as Topic
Autopsy
Biomarkers
Chloride Channels
Female
Gene Expression
Gene Expression Profiling
Humans
Macaca
Male
Middle Aged
Nerve Net
Neural Pathways
Neurons
Nucleus Accumbens
Oligodendroglia
Parvalbumins
Prefrontal Cortex
Somatostatin
Temporal Lobe
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Anderson, K.M, Krienen, F.M, Choi, E.Y, Reinen, J.M, Yeo, B.T.T, Holmes, A.J (2018). Gene expression links functional networks across cortex and striatum. Nature Communications 9 (1) : 1428. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-03811-x
Rights: Attribution 4.0 International
Abstract: The human brain is comprised of a complex web of functional networks that link anatomically distinct regions. However, the biological mechanisms supporting network organization remain elusive, particularly across cortical and subcortical territories with vastly divergent cellular and molecular properties. Here, using human and primate brain transcriptional atlases, we demonstrate that spatial patterns of gene expression show strong correspondence with limbic and somato/motor cortico-striatal functional networks. Network-associated expression is consistent across independent human datasets and evolutionarily conserved in non-human primates. Genes preferentially expressed within the limbic network (encompassing nucleus accumbens, orbital/ventromedial prefrontal cortex, and temporal pole) relate to risk for psychiatric illness, chloride channel complexes, and markers of somatostatin neurons. Somato/motor associated genes are enriched for oligodendrocytes and markers of parvalbumin neurons. These analyses indicate that parallel cortico-striatal processing channels possess dissociable genetic signatures that recapitulate distributed functional networks, and nominate molecular mechanisms supporting cortico-striatal circuitry in health and disease. © 2018 The Author(s).
Source Title: Nature Communications
URI: https://scholarbank.nus.edu.sg/handle/10635/178417
ISSN: 2041-1723
DOI: 10.1038/s41467-018-03811-x
Rights: Attribution 4.0 International
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