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https://doi.org/10.1038/s41598-017-06287-9
Title: | Common shared genetic variation behind decreased risk of breast cancer in celiac disease | Authors: | Ugalde-Morales, E Li, J Humphreys, K Ludvigsson, J.F Yang, H Hall, P Czene, K |
Keywords: | breast tumor celiac disease chromosomal mapping complication female gene linkage disequilibrium genetic predisposition genetic variation genetics human risk factor single nucleotide polymorphism Breast Neoplasms Celiac Disease Chromosome Mapping Female Genetic Predisposition to Disease Genetic Variation Humans Linkage Disequilibrium Polymorphism, Single Nucleotide Risk Factors |
Issue Date: | 2017 | Citation: | Ugalde-Morales, E, Li, J, Humphreys, K, Ludvigsson, J.F, Yang, H, Hall, P, Czene, K (2017). Common shared genetic variation behind decreased risk of breast cancer in celiac disease. Scientific Reports 7 (1) : 5942. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-06287-9 | Rights: | Attribution 4.0 International | Abstract: | There is epidemiologic evidence showing that women with celiac disease have reduced risk of later developing breast cancer, however, the etiology of this association is unclear. Here, we assess the extent of genetic overlap between the two diseases. Through analyses of summary statistics on densely genotyped immunogenic regions, we show a significant genetic correlation (r = -0.17, s.e. 0.05, P < 0.001) and overlap (Ppermuted < 0.001) between celiac disease and breast cancer. Using individual-level genotype data from a Swedish cohort, we find higher genetic susceptibility to celiac disease summarized by polygenic risk scores to be associated with lower breast cancer risk (ORper-SD, 0.94, 95% CI 0.91 to 0.98). Common single nucleotide polymorphisms between the two diseases, with low P-values (PCD < 1.00E-05, PBC ? 0.05), mapped onto genes enriched for immunoregulatory and apoptotic processes. Our results suggest that the link between breast cancer and celiac disease is due to a shared polygenic variation of immune related regions, uncovering pathways which might be important for their development. © 2017 The Author(s). | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/178314 | ISSN: | 20452322 | DOI: | 10.1038/s41598-017-06287-9 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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