Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-06287-9
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dc.titleCommon shared genetic variation behind decreased risk of breast cancer in celiac disease
dc.contributor.authorUgalde-Morales, E
dc.contributor.authorLi, J
dc.contributor.authorHumphreys, K
dc.contributor.authorLudvigsson, J.F
dc.contributor.authorYang, H
dc.contributor.authorHall, P
dc.contributor.authorCzene, K
dc.date.accessioned2020-10-20T09:10:45Z
dc.date.available2020-10-20T09:10:45Z
dc.date.issued2017
dc.identifier.citationUgalde-Morales, E, Li, J, Humphreys, K, Ludvigsson, J.F, Yang, H, Hall, P, Czene, K (2017). Common shared genetic variation behind decreased risk of breast cancer in celiac disease. Scientific Reports 7 (1) : 5942. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-06287-9
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178314
dc.description.abstractThere is epidemiologic evidence showing that women with celiac disease have reduced risk of later developing breast cancer, however, the etiology of this association is unclear. Here, we assess the extent of genetic overlap between the two diseases. Through analyses of summary statistics on densely genotyped immunogenic regions, we show a significant genetic correlation (r = -0.17, s.e. 0.05, P < 0.001) and overlap (Ppermuted < 0.001) between celiac disease and breast cancer. Using individual-level genotype data from a Swedish cohort, we find higher genetic susceptibility to celiac disease summarized by polygenic risk scores to be associated with lower breast cancer risk (ORper-SD, 0.94, 95% CI 0.91 to 0.98). Common single nucleotide polymorphisms between the two diseases, with low P-values (PCD < 1.00E-05, PBC ? 0.05), mapped onto genes enriched for immunoregulatory and apoptotic processes. Our results suggest that the link between breast cancer and celiac disease is due to a shared polygenic variation of immune related regions, uncovering pathways which might be important for their development. © 2017 The Author(s).
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectbreast tumor
dc.subjectceliac disease
dc.subjectchromosomal mapping
dc.subjectcomplication
dc.subjectfemale
dc.subjectgene linkage disequilibrium
dc.subjectgenetic predisposition
dc.subjectgenetic variation
dc.subjectgenetics
dc.subjecthuman
dc.subjectrisk factor
dc.subjectsingle nucleotide polymorphism
dc.subjectBreast Neoplasms
dc.subjectCeliac Disease
dc.subjectChromosome Mapping
dc.subjectFemale
dc.subjectGenetic Predisposition to Disease
dc.subjectGenetic Variation
dc.subjectHumans
dc.subjectLinkage Disequilibrium
dc.subjectPolymorphism, Single Nucleotide
dc.subjectRisk Factors
dc.typeArticle
dc.contributor.departmentSURGERY
dc.description.doi10.1038/s41598-017-06287-9
dc.description.sourcetitleScientific Reports
dc.description.volume7
dc.description.issue1
dc.description.page5942
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