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Title: Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities
Authors: Ramanathan, N
Tan, E
Loh, L.J
Soh, B.S 
Yap, W.N
Keywords: alpha tocopherol
alpha tocotrienol
ascorbic acid
reactive oxygen metabolite
antiinflammatory activity
antioxidant activity
atrial fibrillation
cardiovascular disease
dietary intake
disorders of mitochondrial functions
heart failure
heart muscle ischemia
heart protection
lipid peroxidation
oxidative stress
Issue Date: 2018
Citation: Ramanathan, N, Tan, E, Loh, L.J, Soh, B.S, Yap, W.N (2018). Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities. Nutrition and Metabolism 15 (1) : 6. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Ageing is a nonmodifiable risk factor that is linked to increased likelihood of cardiovascular morbidities. Whilst many pharmacological interventions currently exist to treat many of these disorders such as statins for hypercholesterolemia or beta-blockers for hypertension, the elderly appear to present a greater likelihood of suffering non-related side effects such as increased risk of developing new onset type 2 diabetes (NODM). In some cases, lower efficacy in the elderly have also been reported. Alternative forms of treatment have been sought to address these issues, and there has been a growing interest in looking at herbal remedies or plant-based natural compounds. Oxidative stress and inflammation are implicated in the manifestation of ageing-related cardiovascular disease. Thus, it is natural that a compound that possesses both antioxidative and anti-inflammatory bioactivities would be considered. This review article examines the potential of tocotrienols, a class of Vitamin E compounds with proven superior antioxidative and anti-inflammatory activity compared to tocopherols (the other class of Vitamin E compounds), in ameliorating ageing-related cardiovascular diseases and its associated morbidities. In particular, the potential of tocotrienols in improving inflammaging, dyslipidemia and mitochondrial dysfunction in ageing-related cardiovascular diseases are discussed. © 2018 The Author(s).
Source Title: Nutrition and Metabolism
ISSN: 17437075
DOI: 10.1186/s12986-018-0244-4
Rights: Attribution 4.0 International
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