Please use this identifier to cite or link to this item: https://doi.org/10.1186/s13195-017-0333-z
Title: A novel language-neutral Visual Cognitive Assessment Test (VCAT): Validation in four Southeast Asian countries
Authors: Lim, L
Ng, T.P 
Ong, A.P
Tan, M.P
Cenina, A.R
Gao, Q 
Ng, A
Kandiah, N
Keywords: adaptation
aged
Alzheimer disease
Article
clinical effectiveness
cognitive defect
controlled study
dementia
dementia assessment
female
human
linguistics
major clinical study
male
mild cognitive impairment
Montreal cognitive assessment
priority journal
prospective study
Southeast Asian
validation study
Visual Cognitive Assessment Test
Alzheimer disease
clinical trial
cognitive defect
cultural anthropology
language
multicenter study
neuropsychological test
photostimulation
receiver operating characteristic
Southeast Asia
Aged
Alzheimer Disease
Asia, Southeastern
Cognitive Dysfunction
Culture
Female
Humans
Language
Male
Neuropsychological Tests
Photic Stimulation
Prospective Studies
ROC Curve
Issue Date: 2018
Citation: Lim, L, Ng, T.P, Ong, A.P, Tan, M.P, Cenina, A.R, Gao, Q, Ng, A, Kandiah, N (2018). A novel language-neutral Visual Cognitive Assessment Test (VCAT): Validation in four Southeast Asian countries. Alzheimer's Research and Therapy 10 (1) : 6. ScholarBank@NUS Repository. https://doi.org/10.1186/s13195-017-0333-z
Rights: Attribution 4.0 International
Abstract: Background: Cognitive screeners are imperative for early diagnosis of dementia. The Visual Cognitive Assessment Test (VCAT) is a language-neutral, visual-based test which has proven useful for a multilingual population in a single-center study. However, its performance utility is unknown in a wider and more diverse Southeast Asian cohort. Methods: We recruited 164 healthy controls (HC) and 120 cognitively impaired (CI) subjects- 47 mild cognitive impairment (MCI) and 73 mild Alzheimer's disease (AD) dementia participants, from four countries between January 2015 and August 2016 to determine the usefulness of a single version of the VCAT, without translation or adaptation, in a multinational, multilingual population. The VCAT was administered along with established cognitive evaluation. Results: The VCAT, without local translation or adaptation, was effective in discriminating between HC and CI subjects (MCI and mild AD dementia). Mean (SD) VCAT scores for HC and CI subjects were 22.48 (3.50) and 14.17 (5.05) respectively. Areas under the curve for Montreal Cognitive Assessment (0.916, 95% CI 0.884-0.948) and the VCAT (0.905, 95% CI 0.870-0.940) in discriminating between HCs and CIs were comparable. The multiple languages used to administer VCAT in four countries did not significantly influence test scores. Conclusions: The VCAT without the need for language translation or cultural adaptation showed satisfactory discriminative ability and was effective in a multinational, multilingual Southeast Asian population. © 2018 The Author(s).
Source Title: Alzheimer's Research and Therapy
URI: https://scholarbank.nus.edu.sg/handle/10635/178110
ISSN: 17589193
DOI: 10.1186/s13195-017-0333-z
Rights: Attribution 4.0 International
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