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Title: A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; Expanding the use of Vi polysaccharide vaccine in Southeast China: A cluster-randomized trial
Authors: Yang, J
Acosta, C.J
Si, G.-A
Zeng, J
Li, C.-Y
Liang, D
Ochiai, R.L
Page, A.-L
Danovaro-Holliday, M.C
Zhang, J
Zhou, B.-D
Liao, H.-Z
Wang, M.-L
Tan, D.-M
Tang, Z.-Z
Gong, J
Park, J.-K
Ali, M
Ivanoff, B
Liang, G.-C
Yang, H.-H
Pang, T 
Xu, Z.-Y
Donner, A
Galindo, C.M
Dong, B.-Q
Clemens, J.D
Keywords: hepatitis B vaccine
Meningococcus vaccine
polysaccharide vaccine
typhoid vaccine
bacterial antigen
bacterial polysaccharide
Meningococcus vaccine
typhoid paratyphoid vaccine
clinical trial
controlled clinical trial
controlled study
drug safety
drug use
feasibility study
groups by age
health program
hepatitis B
infection prevention
injection site reaction
mass immunization
medical documentation
normal human
randomized controlled trial
single drug dose
statistical analysis
storage temperature
typhoid fever
vaccination reaction
cluster analysis
intramuscular drug administration
mass immunization
Meningitis, Meningococcal
middle aged
organization and management
public health service
social marketing
subcutaneous drug administration
typhoid fever
Antigens, Bacterial
Cluster Analysis
Feasibility Studies
Injections, Intramuscular
Injections, Subcutaneous
Mass Vaccination
Meningitis, Meningococcal
Meningococcal Vaccines
Middle Aged
Polysaccharides, Bacterial
Public Health Administration
Social Marketing
Typhoid Fever
Typhoid-Paratyphoid Vaccines
Issue Date: 2005
Citation: Yang, J, Acosta, C.J, Si, G.-A, Zeng, J, Li, C.-Y, Liang, D, Ochiai, R.L, Page, A.-L, Danovaro-Holliday, M.C, Zhang, J, Zhou, B.-D, Liao, H.-Z, Wang, M.-L, Tan, D.-M, Tang, Z.-Z, Gong, J, Park, J.-K, Ali, M, Ivanoff, B, Liang, G.-C, Yang, H.-H, Pang, T, Xu, Z.-Y, Donner, A, Galindo, C.M, Dong, B.-Q, Clemens, J.D (2005). A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; Expanding the use of Vi polysaccharide vaccine in Southeast China: A cluster-randomized trial. BMC Public Health 5 : 49. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background: One of the goals of this study was to learn the coverage, safety and logistics of a mass vaccination campaign against typhoid fever in children and adults using locally produced typhoid Vi polysaccharide (PS) and group A meningococcal PS vaccines in southern China. Methods: The vaccination campaign targeted 118,588 persons in Hechi, Guangxi Province, aged between 5 to 60 years, in 2003. The study area was divided into 107 geographic clusters, which were randomly allocated to receive one of the single-dose parenteral vaccines. All aspects regarding vaccination logistics, feasibility and safety were documented and systematically recorded. Results of the logistics, feasibility and safety are reported. Results: The campaign lasted 5 weeks and the overall vaccination coverage was 78%. On average, the 30 vaccine teams gave immunizations on 23 days. Vaccine rates were higher in those aged ? 15 years (90%) than in adolescents and young adults (70%). Planned mop-up activities increased the coverage by 17%. The overall vaccine wastage was 11%. The cold chain was maintained and documented. 66 individuals reported of adverse events out of all vaccinees, where fever (21%), malaise (19%) and local redness (19%) were the major symptoms; no life-threatening event occurred. Three needle-sharp events were reported. Conclusion: The mass immunization proved feasible and safe, and vaccine coverage was high. Emphasis should be placed on: injection safety measures, community involvement and incorporation of mop-up strategies into any vaccination campaign. School-based and all-age Vi mass immunizations programs are potentially important public health strategies for prevention of typhoid fever in high-risk populations in southern China. © 2005 Yang et al; licensee BioMed Central Ltd.
Source Title: BMC Public Health
ISSN: 14712458
DOI: 10.1186/1471-2458-5-49
Rights: Attribution 4.0 International
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