Please use this identifier to cite or link to this item: https://doi.org/10.1186/1475-2891-5-20
Title: A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: The Older People and n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636]
Authors: Alan, D.D
Clemens, F
Elbourne, D
Fasey, N
Fletcher, A.E
Hardy, P
Holder, G.E 
Huppert, F.A
Knight, R
Letley, L
Richards, M
Truesdale, A
Vickers, M
Uauy, R
Keywords: docosahexaenoic acid
icosapentaenoic acid
olive oil
placebo
polyunsaturated fatty acid
docosahexaenoic acid
icosapentaenoic acid
omega 3 fatty acid
aged
article
brain function
clinical trial
cognition
cognitive defect
controlled clinical trial
controlled study
diet supplementation
dietary intake
double blind procedure
function test
human
medical research
nervous tissue
normal human
outcome assessment
quality of life
randomized controlled trial
retina
vision
visual disorder
aging
cognitive defect
diet supplementation
physiology
randomized controlled trial (topic)
retina
United Kingdom
Aged
Aging
Cognition
Cognition Disorders
Dietary Supplements
Docosahexaenoic Acids
Double-Blind Method
Eicosapentaenoic Acid
Fatty Acids, Omega-3
Great Britain
Humans
Placebos
Randomized Controlled Trials as Topic
Retina
Issue Date: 2006
Citation: Alan, D.D, Clemens, F, Elbourne, D, Fasey, N, Fletcher, A.E, Hardy, P, Holder, G.E, Huppert, F.A, Knight, R, Letley, L, Richards, M, Truesdale, A, Vickers, M, Uauy, R (2006). A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: The Older People and n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636]. Nutrition Journal 5 : 20. ScholarBank@NUS Repository. https://doi.org/10.1186/1475-2891-5-20
Rights: Attribution 4.0 International
Abstract: The number of individuals with age-related cognitive impairment is rising dramatically in the UK and globally. There is considerable interest in the general hypothesis that improving the diet of older people may slow the progression of cognitive decline. To date, there has been little attention given to the possible protective role of n-3 long-chain polyunsaturated fatty acids (n-3 LCPs) most commonly found in oily fish, in age-related loss of cognitive function. The main research hypothesis of this study is that an increased dietary intake of n-3 LCPs will have a positive effect on cognitive performance in older people in the UK. To test this hypothesis, a double-blind randomised placebo-controlled trial will be carried out among adults aged 70-79 years in which the intervention arm will receive daily capsules containing n-3 LCP (0.5 g/day docosahexaenoic acid and 0.2 g/day eicosapentaenoic acid) while the placebo arm will receive daily capsules containing olive oil. The main outcome variable assessed at 24 months will be cognitive performance and a second major outcome variable will be retinal function. Retinal function tests are included as the retina is a specifically differentiated neural tissue and therefore represents an accessible window into the functioning of the brain. The overall purpose of this public-health research is to help define a simple and effective dietary intervention aimed at maintaining cognitive and retinal function in later life. This will be the first trial of its kind aiming to slow the decline of cognitive and retinal function in older people by increasing daily dietary intake of n-3 LCPs. The link between cognitive ability, visual function and quality of life among older people suggests that this novel line of research may have considerable public health importance. © 2006 Alan et al; licensee BioMed Central Ltd.
Source Title: Nutrition Journal
URI: https://scholarbank.nus.edu.sg/handle/10635/178014
ISSN: 14752891
DOI: 10.1186/1475-2891-5-20
Rights: Attribution 4.0 International
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