A hypothetical index of hypothalamic-pituitary-adrenal (HPA) axis function

Please use this identifier to cite or link to this item: https://doi.org/10.1055/s-2005-861030

Title:	A hypothetical index of hypothalamic-pituitary-adrenal (HPA) axis function
Authors:	Leow M.K.S.
Keywords:	Adrenocortical insufficiency Corticotropin stimulation test Mathematical model
Issue Date:	2005
Citation:	Leow M.K.S. (2005). A hypothetical index of hypothalamic-pituitary-adrenal (HPA) axis function. Hormone and Metabolic Research 37 (1) : 1-3. ScholarBank@NUS Repository. https://doi.org/10.1055/s-2005-861030
Abstract:	The short ACTH stimulation test (SST) is commonly used by clinicians to determine the integrity of the hypothalamic-pituitary-adrenal (HPA) axis in cases of suspected adrenal insufficiency. Concern has arisen for under-diagnosis of central hypocortisolism using the standard dose (250mcg) SST with the recent introduction of low-dose (1mcg) SST as a potentially more sensitive test for central hypocortisolism. Amidst this uncertainty, I will present a novel index hypothesized to extend the sensitivity of the standard dose SST as an adjunctive diagnostic tool for any level of hypocortisolism.
Source Title:	Hormone and Metabolic Research
URI:	https://scholarbank.nus.edu.sg/handle/10635/177456
ISSN:	00185043
DOI:	10.1055/s-2005-861030
Appears in Collections:	Staff Publications

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