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Title: Markers of T cell senescence in humans
Authors: Xu, W
Larbi, A 
Keywords: CD27 antigen
CD28 antigen
CD45RA antigen
CD45RO antigen
CD57 antigen
chemokine receptor CCR7
gamma interferon
granzyme B
interleukin 2
interleukin 4
interleukin 5
natural killer cell lectin like receptor
protein p16
protein p21
telomerase reverse transcriptase
transcription factor T bet
tumor necrosis factor
zinc finger protein
cell assay
cell cycle
cell differentiation
cell function
cell proliferation
flow cytometry
mucosal-associated invariant T cell
natural killer T cell
persistent infection
signal transduction
T lymphocyte
cell aging
T lymphocyte
Cell Differentiation
Cellular Senescence
Issue Date: 2017
Citation: Xu, W, Larbi, A (2017). Markers of T cell senescence in humans. International Journal of Molecular Sciences 18 (8) : 1742. ScholarBank@NUS Repository.
Abstract: Many countries are facing the aging of their population, and many more will face a similar obstacle in the near future, which could be a burden to many healthcare systems. Increased susceptibility to infections, cardiovascular and neurodegenerative disease, cancer as well as reduced efficacy of vaccination are important matters for researchers in the field of aging. As older adults show higher prevalence for a variety of diseases, this also implies higher risk of complications, including nosocomial infections, slower recovery and sequels that may reduce the autonomy and overall quality of life of older adults. The age-related effects on the immune system termed as “immunosenescence” can be exemplified by the reported hypo-responsiveness to influenza vaccination of the elderly. T cells, which belong to the adaptive arm of the immune system, have been extensively studied and the knowledge gathered enables a better understanding of how the immune system may be affected after acute/chronic infections and how this matters in the long run. In this review, we will focus on T cells and discuss the surface and molecular markers that are associated with T cell senescence. We will also look at the implications that senescent T cells could have on human health and diseases. Finally, we will discuss the benefits of having these markers for investigators and the future work that is needed to advance the field of T cell senescence markers. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
ISSN: 1661-6596
DOI: 10.3390/ijms18081742
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