Please use this identifier to cite or link to this item:
https://doi.org/10.3390/ijms18081742
DC Field | Value | |
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dc.title | Markers of T cell senescence in humans | |
dc.contributor.author | Xu, W | |
dc.contributor.author | Larbi, A | |
dc.date.accessioned | 2020-09-14T08:02:35Z | |
dc.date.available | 2020-09-14T08:02:35Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Xu, W, Larbi, A (2017). Markers of T cell senescence in humans. International Journal of Molecular Sciences 18 (8) : 1742. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms18081742 | |
dc.identifier.issn | 1661-6596 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/176084 | |
dc.description.abstract | Many countries are facing the aging of their population, and many more will face a similar obstacle in the near future, which could be a burden to many healthcare systems. Increased susceptibility to infections, cardiovascular and neurodegenerative disease, cancer as well as reduced efficacy of vaccination are important matters for researchers in the field of aging. As older adults show higher prevalence for a variety of diseases, this also implies higher risk of complications, including nosocomial infections, slower recovery and sequels that may reduce the autonomy and overall quality of life of older adults. The age-related effects on the immune system termed as “immunosenescence” can be exemplified by the reported hypo-responsiveness to influenza vaccination of the elderly. T cells, which belong to the adaptive arm of the immune system, have been extensively studied and the knowledge gathered enables a better understanding of how the immune system may be affected after acute/chronic infections and how this matters in the long run. In this review, we will focus on T cells and discuss the surface and molecular markers that are associated with T cell senescence. We will also look at the implications that senescent T cells could have on human health and diseases. Finally, we will discuss the benefits of having these markers for investigators and the future work that is needed to advance the field of T cell senescence markers. © 2017 by the authors. Licensee MDPI, Basel, Switzerland. | |
dc.source | Unpaywall 20200831 | |
dc.subject | CD27 antigen | |
dc.subject | CD28 antigen | |
dc.subject | CD45RA antigen | |
dc.subject | CD45RO antigen | |
dc.subject | CD57 antigen | |
dc.subject | chemokine receptor CCR7 | |
dc.subject | gamma interferon | |
dc.subject | granzyme B | |
dc.subject | interleukin 2 | |
dc.subject | interleukin 4 | |
dc.subject | interleukin 5 | |
dc.subject | natural killer cell lectin like receptor | |
dc.subject | perforin | |
dc.subject | protein p16 | |
dc.subject | protein p21 | |
dc.subject | telomerase reverse transcriptase | |
dc.subject | transcription factor T bet | |
dc.subject | tumor necrosis factor | |
dc.subject | zinc finger protein | |
dc.subject | aging | |
dc.subject | cell assay | |
dc.subject | cell cycle | |
dc.subject | cell differentiation | |
dc.subject | cell function | |
dc.subject | cell proliferation | |
dc.subject | flow cytometry | |
dc.subject | human | |
dc.subject | immunosenescence | |
dc.subject | mucosal-associated invariant T cell | |
dc.subject | natural killer T cell | |
dc.subject | persistent infection | |
dc.subject | phenotype | |
dc.subject | Review | |
dc.subject | signal transduction | |
dc.subject | T lymphocyte | |
dc.subject | cell aging | |
dc.subject | cytology | |
dc.subject | immunology | |
dc.subject | immunophenotyping | |
dc.subject | procedures | |
dc.subject | T lymphocyte | |
dc.subject | Aging | |
dc.subject | Cell Differentiation | |
dc.subject | Cellular Senescence | |
dc.subject | Humans | |
dc.subject | Immunophenotyping | |
dc.subject | Immunosenescence | |
dc.subject | T-Lymphocytes | |
dc.type | Review | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.description.doi | 10.3390/ijms18081742 | |
dc.description.sourcetitle | International Journal of Molecular Sciences | |
dc.description.volume | 18 | |
dc.description.issue | 8 | |
dc.description.page | 1742 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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