Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep14355
Title: Divergent Synthesis of Chondroitin Sulfate Disaccharides and Identification of Sulfate Motifs that Inhibit Triple Negative Breast Cancer
Authors: Poh, Z.W 
Gan, C.H 
Lee, E.J 
Guo, S 
Yip, G.W 
Lam, Y 
Keywords: antineoplastic agent
caspase 3
caspase 7
chondroitin sulfate
cell survival
chemical structure
drug effects
enzyme activation
glycosylation
human
metabolism
synthesis
triple negative breast cancer
tumor cell line
Antineoplastic Agents
Caspase 3
Caspase 7
Cell Line, Tumor
Cell Survival
Chondroitin Sulfates
Enzyme Activation
Glycosylation
Humans
Molecular Structure
Triple Negative Breast Neoplasms
Issue Date: 2015
Citation: Poh, Z.W, Gan, C.H, Lee, E.J, Guo, S, Yip, G.W, Lam, Y (2015). Divergent Synthesis of Chondroitin Sulfate Disaccharides and Identification of Sulfate Motifs that Inhibit Triple Negative Breast Cancer. Scientific reports 5 : 14355. ScholarBank@NUS Repository. https://doi.org/10.1038/srep14355
Abstract: Glycosaminoglycans (GAGs) regulate many important physiological processes. A pertinent issue to address is whether GAGs encode important functional information via introduction of position specific sulfate groups in the GAG structure. However, procurement of pure, homogenous GAG motifs to probe the "sulfation code" is a challenging task due to isolation difficulty and structural complexity. To this end, we devised a versatile synthetic strategy to obtain all the 16 theoretically possible sulfation patterns in the chondroitin sulfate (CS) repeating unit; these include rare but potentially important sulfated motifs which have not been isolated earlier. Biological evaluation indicated that CS sulfation patterns had differing effects for different breast cancer cell types, and the greatest inhibitory effect was observed for the most aggressive, triple negative breast cancer cell line MDA-MB-231.
Source Title: Scientific reports
URI: https://scholarbank.nus.edu.sg/handle/10635/176009
ISSN: 2045-2322
DOI: 10.1038/srep14355
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