Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep14355
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dc.titleDivergent Synthesis of Chondroitin Sulfate Disaccharides and Identification of Sulfate Motifs that Inhibit Triple Negative Breast Cancer
dc.contributor.authorPoh, Z.W
dc.contributor.authorGan, C.H
dc.contributor.authorLee, E.J
dc.contributor.authorGuo, S
dc.contributor.authorYip, G.W
dc.contributor.authorLam, Y
dc.date.accessioned2020-09-14T07:42:49Z
dc.date.available2020-09-14T07:42:49Z
dc.date.issued2015
dc.identifier.citationPoh, Z.W, Gan, C.H, Lee, E.J, Guo, S, Yip, G.W, Lam, Y (2015). Divergent Synthesis of Chondroitin Sulfate Disaccharides and Identification of Sulfate Motifs that Inhibit Triple Negative Breast Cancer. Scientific reports 5 : 14355. ScholarBank@NUS Repository. https://doi.org/10.1038/srep14355
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/176009
dc.description.abstractGlycosaminoglycans (GAGs) regulate many important physiological processes. A pertinent issue to address is whether GAGs encode important functional information via introduction of position specific sulfate groups in the GAG structure. However, procurement of pure, homogenous GAG motifs to probe the "sulfation code" is a challenging task due to isolation difficulty and structural complexity. To this end, we devised a versatile synthetic strategy to obtain all the 16 theoretically possible sulfation patterns in the chondroitin sulfate (CS) repeating unit; these include rare but potentially important sulfated motifs which have not been isolated earlier. Biological evaluation indicated that CS sulfation patterns had differing effects for different breast cancer cell types, and the greatest inhibitory effect was observed for the most aggressive, triple negative breast cancer cell line MDA-MB-231.
dc.sourceUnpaywall 20200831
dc.subjectantineoplastic agent
dc.subjectcaspase 3
dc.subjectcaspase 7
dc.subjectchondroitin sulfate
dc.subjectcell survival
dc.subjectchemical structure
dc.subjectdrug effects
dc.subjectenzyme activation
dc.subjectglycosylation
dc.subjecthuman
dc.subjectmetabolism
dc.subjectsynthesis
dc.subjecttriple negative breast cancer
dc.subjecttumor cell line
dc.subjectAntineoplastic Agents
dc.subjectCaspase 3
dc.subjectCaspase 7
dc.subjectCell Line, Tumor
dc.subjectCell Survival
dc.subjectChondroitin Sulfates
dc.subjectEnzyme Activation
dc.subjectGlycosylation
dc.subjectHumans
dc.subjectMolecular Structure
dc.subjectTriple Negative Breast Neoplasms
dc.typeArticle
dc.contributor.departmentDEPT OF ANATOMY
dc.contributor.departmentDEPT OF CHEMISTRY
dc.description.doi10.1038/srep14355
dc.description.sourcetitleScientific reports
dc.description.volume5
dc.description.page14355
dc.published.statePublished
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