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https://doi.org/10.1038/ncomms8270
| Title: | Identification of new susceptibility loci for IgA nephropathy in Han Chinese | Authors: | Li M. Foo J.-N. Wang J.-Q. Low H.-Q. Tang X.-Q. Toh K.-Y. Yin P.-R. Khor C.-C. Goh Y.-F. Irwan I.D. Xu R.-C. Andiappan A.K. Bei J.-X. Rotzschke O. Chen M.-H. Cheng C.-Y. Sun L.-D. Jiang G.-R. Wong T.-Y. Lin H.-L. Aung T. Liao Y.-H. Saw S.-M. Ye K. Ebstein R.P. Chen Q.-K. Shi W. Chew S.-H. Chen J. Zhang F.-R. Li S.-P. Xu G. Tai E.S. Wang L. Chen N. Zhang X.-J. Zeng Y.-X. Zhang H. Liu Z.-H. Yu X.-Q. Liu J.-J. |
Keywords: | messenger RNA 1-aminocyclopropanecarboxylate synthase CD11b antigen deficiens protein early growth response factor glycoprotein p 15095 heat shock protein ITGAM protein, human KLF10 protein, human kruppel like factor leukocyte antigen lyase ODF1 protein, human sialyltransferase ST6GAL1 protein, human blood cell organelle disease prevalence ethnic group gene expression genetic variation geographical variation immune response risk factor signaling ACCS gene Article blood cell controlled study DEFA gene female gene gene cluster gene expression gene frequency gene identification gene linkage disequilibrium gene locus genetic association genetic susceptibility genetic variability Han Chinese HLA system human immunoglobulin A nephropathy ITGAX ITGAM gene major clinical study major histocompatibility complex male ODF1 KLF10 gene quantitative trait locus ST6GAL1 gene validation study adult Asian continental ancestry group case control study China genetic predisposition genetics genome-wide association study immunoglobulin A nephropathy middle aged odds ratio single nucleotide polymorphism young adult China Adult Antigens, CD Antigens, CD11b Antigens, CD11c Asian Continental Ancestry Group Case-Control Studies China DEFICIENS Protein Early Growth Response Transcription Factors Female Genetic Predisposition to Disease Genome-Wide Association Study Glomerulonephritis, IGA Heat-Shock Proteins Humans Kruppel-Like Transcription Factors Lyases Male Middle Aged Odds Ratio Polymorphism, Single Nucleotide Sialyltransferases Young Adult |
Issue Date: | 2015 | Publisher: | Nature Publishing Group | Citation: | Li M., Foo J.-N., Wang J.-Q., Low H.-Q., Tang X.-Q., Toh K.-Y., Yin P.-R., Khor C.-C., Goh Y.-F., Irwan I.D., Xu R.-C., Andiappan A.K., Bei J.-X., Rotzschke O., Chen M.-H., Cheng C.-Y., Sun L.-D., Jiang G.-R., Wong T.-Y., Lin H.-L., Aung T., Liao Y.-H., Saw S.-M., Ye K., Ebstein R.P., Chen Q.-K., Shi W., Chew S.-H., Chen J., Zhang F.-R., Li S.-P., Xu G., Tai E.S., Wang L., Chen N., Zhang X.-J., Zeng Y.-X., Zhang H., Liu Z.-H., Yu X.-Q., Liu J.-J. (2015). Identification of new susceptibility loci for IgA nephropathy in Han Chinese. Nature Communications 6 : 7270. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms8270 | Abstract: | IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis. Previously identified genome-wide association study (GWAS) loci explain only a fraction of disease risk. To identify novel susceptibility loci in Han Chinese, we conduct a four-stage GWAS comprising 8,313 cases and 19,680 controls. Here, we show novel associations at ST6GAL1 on 3q27.3 (rs7634389, odds ratio (OR)=1.13, P=7.27 × 10-10), ACCS on 11p11.2 (rs2074038, OR=1.14, P=3.93 × 10-9) and ODF1-KLF10 on 8q22.3 (rs2033562, OR=1.13, P=1.41 × 10-9), validate a recently reported association at ITGAX-ITGAM on 16p11.2 (rs7190997, OR=1.22, P=2.26 × 10-19), and identify three independent signals within the DEFA locus (rs2738058, P=1.15 × 10-19; rs12716641, P=9.53 × 10-9; rs9314614, P=4.25 × 10-9, multivariate association). The risk variants on 3q27.3 and 11p11.2 show strong association with mRNA expression levels in blood cells while allele frequencies of the risk variants within ST6GAL1, ACCS and DEFA correlate with geographical variation in IgAN prevalence. Our findings expand our understanding on IgAN genetic susceptibility and provide novel biological insights into molecular mechanisms underlying IgAN. © 2015 Macmillan Publishers Limited. All rights reserved. | Source Title: | Nature Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/175509 | ISSN: | 20411723 | DOI: | 10.1038/ncomms8270 |
| Appears in Collections: | Staff Publications Elements |
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