Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep17958
Title: Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference
Authors: Wen W.
Kato N.
Hwang J.-Y.
Liu J.-J. 
Tai E.S. 
Keywords: Asia
Asian continental ancestry group
female
genetic predisposition
genetics
genome-wide association study
human
male
meta analysis
obesity
quantitative trait
quantitative trait locus
sex difference
single nucleotide polymorphism
waist circumference
waist hip ratio
Asia
Asian Continental Ancestry Group
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Obesity
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Quantitative Trait, Heritable
Sex Factors
Waist Circumference
Waist-Hip Ratio
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: Wen W., Kato N., Hwang J.-Y., Liu J.-J., Tai E.S. (2016). Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Scientific Reports 6 : 17985. ScholarBank@NUS Repository. https://doi.org/10.1038/srep17958
Abstract: Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3, CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/175442
ISSN: 20452322
DOI: 10.1038/srep17958
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