Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep17958
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dc.titleGenome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference
dc.contributor.authorWen W.
dc.contributor.authorKato N.
dc.contributor.authorHwang J.-Y.
dc.contributor.authorLiu J.-J.
dc.contributor.authorTai E.S.
dc.date.accessioned2020-09-10T01:41:52Z
dc.date.available2020-09-10T01:41:52Z
dc.date.issued2016
dc.identifier.citationWen W., Kato N., Hwang J.-Y., Liu J.-J., Tai E.S. (2016). Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Scientific Reports 6 : 17985. ScholarBank@NUS Repository. https://doi.org/10.1038/srep17958
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/175442
dc.description.abstractSixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3, CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.
dc.publisherNature Publishing Group
dc.sourceUnpaywall 20200831
dc.subjectAsia
dc.subjectAsian continental ancestry group
dc.subjectfemale
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjectgenome-wide association study
dc.subjecthuman
dc.subjectmale
dc.subjectmeta analysis
dc.subjectobesity
dc.subjectquantitative trait
dc.subjectquantitative trait locus
dc.subjectsex difference
dc.subjectsingle nucleotide polymorphism
dc.subjectwaist circumference
dc.subjectwaist hip ratio
dc.subjectAsia
dc.subjectAsian Continental Ancestry Group
dc.subjectFemale
dc.subjectGenetic Predisposition to Disease
dc.subjectGenome-Wide Association Study
dc.subjectHumans
dc.subjectMale
dc.subjectObesity
dc.subjectPolymorphism, Single Nucleotide
dc.subjectQuantitative Trait Loci
dc.subjectQuantitative Trait, Heritable
dc.subjectSex Factors
dc.subjectWaist Circumference
dc.subjectWaist-Hip Ratio
dc.typeArticle
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentGENOME INSTITUTE OF SINGAPORE
dc.description.doi10.1038/srep17958
dc.description.sourcetitleScientific Reports
dc.description.volume6
dc.description.page17985
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