Please use this identifier to cite or link to this item: https://doi.org/10.1038/ncomms10432
Title: In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics
Authors: Ai X.
Ho C.J.H.
Aw J.
Attia A.B.E.
Mu J.
Wang Y.
Wang X.
Wang Y.
Liu X. 
Chen H.
Gao M.
Chen X.
Yeow E.K.L.
Liu G.
Olivo M.
Xing B.
Keywords: 2 cyanobenzothiazole
benzothiazole derivative
cathepsin
cysteine
nanomaterial
peptide
photosensitizing agent
singlet oxygen
unclassified drug
upconversion nanoparticle
lanthanide
nanomaterial
benzene
chemical reaction
electron
enzyme activity
medicine
nanoparticle
oxygen
peptide
precision
rare earth element
tumor
animal cell
animal experiment
animal model
animal tissue
Article
chemical reaction
controlled study
covalent bond
cross linking
female
human
human cell
irradiation
mouse
nonhuman
photon
protein cleavage
theranostic nanomedicine
tumor localization
tumor microenvironment
animal
Bagg albino mouse
chemistry
HT-29 cell line
NIH 3T3 cell line
nude mouse
procedures
theranostic nanomedicine
Animals
Female
HT29 Cells
Humans
Metals, Rare Earth
Mice
Mice, Inbred BALB C
Mice, Nude
Nanostructures
NIH 3T3 Cells
Photons
Singlet Oxygen
Theranostic Nanomedicine
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: Ai X., Ho C.J.H., Aw J., Attia A.B.E., Mu J., Wang Y., Wang X., Wang Y., Liu X., Chen H., Gao M., Chen X., Yeow E.K.L., Liu G., Olivo M., Xing B. (2016). In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics. Nature Communications 7 : 10432. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms10432
Abstract: The development of precision nanomedicines to direct nanostructure-based reagents into tumour-targeted areas remains a critical challenge in clinics. Chemical reaction-mediated localization in response to tumour environmental perturbations offers promising opportunities for rational design of effective nano-theranostics. Here, we present a unique microenvironment-sensitive strategy for localization of peptide-premodified upconversion nanocrystals (UCNs) within tumour areas. Upon tumour-specific cathepsin protease reactions, the cleavage of peptides induces covalent cross-linking between the exposed cysteine and 2-cyanobenzothiazole on neighbouring particles, thus triggering the accumulation of UCNs into tumour site. Such enzyme-triggered cross-linking of UCNs leads to enhanced upconversion emission upon 808 nm laser irradiation, and in turn amplifies the singlet oxygen generation from the photosensitizers attached on UCNs. Importantly, this design enables remarkable tumour inhibition through either intratumoral UCNs injection or intravenous injection of nanoparticles modified with the targeting ligand. Our strategy may provide a multimodality solution for effective molecular sensing and site-specific tumour treatment.
Source Title: Nature Communications
URI: https://scholarbank.nus.edu.sg/handle/10635/175441
ISSN: 20411723
DOI: 10.1038/ncomms10432
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