Please use this identifier to cite or link to this item: https://doi.org/10.1038/ncomms10432
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dc.titleIn vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics
dc.contributor.authorAi X.
dc.contributor.authorHo C.J.H.
dc.contributor.authorAw J.
dc.contributor.authorAttia A.B.E.
dc.contributor.authorMu J.
dc.contributor.authorWang Y.
dc.contributor.authorWang X.
dc.contributor.authorWang Y.
dc.contributor.authorLiu X.
dc.contributor.authorChen H.
dc.contributor.authorGao M.
dc.contributor.authorChen X.
dc.contributor.authorYeow E.K.L.
dc.contributor.authorLiu G.
dc.contributor.authorOlivo M.
dc.contributor.authorXing B.
dc.date.accessioned2020-09-10T01:41:39Z
dc.date.available2020-09-10T01:41:39Z
dc.date.issued2016
dc.identifier.citationAi X., Ho C.J.H., Aw J., Attia A.B.E., Mu J., Wang Y., Wang X., Wang Y., Liu X., Chen H., Gao M., Chen X., Yeow E.K.L., Liu G., Olivo M., Xing B. (2016). In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics. Nature Communications 7 : 10432. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms10432
dc.identifier.issn20411723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/175441
dc.description.abstractThe development of precision nanomedicines to direct nanostructure-based reagents into tumour-targeted areas remains a critical challenge in clinics. Chemical reaction-mediated localization in response to tumour environmental perturbations offers promising opportunities for rational design of effective nano-theranostics. Here, we present a unique microenvironment-sensitive strategy for localization of peptide-premodified upconversion nanocrystals (UCNs) within tumour areas. Upon tumour-specific cathepsin protease reactions, the cleavage of peptides induces covalent cross-linking between the exposed cysteine and 2-cyanobenzothiazole on neighbouring particles, thus triggering the accumulation of UCNs into tumour site. Such enzyme-triggered cross-linking of UCNs leads to enhanced upconversion emission upon 808 nm laser irradiation, and in turn amplifies the singlet oxygen generation from the photosensitizers attached on UCNs. Importantly, this design enables remarkable tumour inhibition through either intratumoral UCNs injection or intravenous injection of nanoparticles modified with the targeting ligand. Our strategy may provide a multimodality solution for effective molecular sensing and site-specific tumour treatment.
dc.publisherNature Publishing Group
dc.sourceUnpaywall 20200831
dc.subject2 cyanobenzothiazole
dc.subjectbenzothiazole derivative
dc.subjectcathepsin
dc.subjectcysteine
dc.subjectnanomaterial
dc.subjectpeptide
dc.subjectphotosensitizing agent
dc.subjectsinglet oxygen
dc.subjectunclassified drug
dc.subjectupconversion nanoparticle
dc.subjectlanthanide
dc.subjectnanomaterial
dc.subjectbenzene
dc.subjectchemical reaction
dc.subjectelectron
dc.subjectenzyme activity
dc.subjectmedicine
dc.subjectnanoparticle
dc.subjectoxygen
dc.subjectpeptide
dc.subjectprecision
dc.subjectrare earth element
dc.subjecttumor
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectchemical reaction
dc.subjectcontrolled study
dc.subjectcovalent bond
dc.subjectcross linking
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjectirradiation
dc.subjectmouse
dc.subjectnonhuman
dc.subjectphoton
dc.subjectprotein cleavage
dc.subjecttheranostic nanomedicine
dc.subjecttumor localization
dc.subjecttumor microenvironment
dc.subjectanimal
dc.subjectBagg albino mouse
dc.subjectchemistry
dc.subjectHT-29 cell line
dc.subjectNIH 3T3 cell line
dc.subjectnude mouse
dc.subjectprocedures
dc.subjecttheranostic nanomedicine
dc.subjectAnimals
dc.subjectFemale
dc.subjectHT29 Cells
dc.subjectHumans
dc.subjectMetals, Rare Earth
dc.subjectMice
dc.subjectMice, Inbred BALB C
dc.subjectMice, Nude
dc.subjectNanostructures
dc.subjectNIH 3T3 Cells
dc.subjectPhotons
dc.subjectSinglet Oxygen
dc.subjectTheranostic Nanomedicine
dc.typeArticle
dc.contributor.departmentDEPT OF CHEMISTRY
dc.description.doi10.1038/ncomms10432
dc.description.sourcetitleNature Communications
dc.description.volume7
dc.description.page10432
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