Please use this identifier to cite or link to this item: https://doi.org/10.1038/ncomms10531
Title: Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
Authors: Imamura M.
Takahashi A.
Yamauchi T.
Tai E.S. 
Keywords: diabetes
ethnic group
genetic analysis
health risk
heritability
meta-analysis
Article
ASB3 gene
ATP8B2 gene
CCDC85A gene
DMRTA1 gene
ethnic group
FAM60A gene
gene
gene locus
genetic association
genetic susceptibility
genotype
human
INAFM2 gene
Japanese (people)
major clinical study
meta analysis
MIR4686 gene
non insulin dependent diabetes mellitus
single nucleotide polymorphism
Asian continental ancestry group
case control study
genetic predisposition
genetics
genome-wide association study
Japan
non insulin dependent diabetes mellitus
Japan
ASB3 protein, human
DMRTA1 protein, human
DNA binding protein
FAM60A protein, human
suppressor of cytokine signaling
transcription factor
Asian Continental Ancestry Group
Case-Control Studies
Diabetes Mellitus, Type 2
DNA-Binding Proteins
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Japan
Polymorphism, Single Nucleotide
Suppressor of Cytokine Signaling Proteins
Transcription Factors
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: Imamura M., Takahashi A., Yamauchi T., Tai E.S. (2016). Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications 7 : 10531. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms10531
Abstract: Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities. © 2016, Nature Publishing Group. All rights reserved.
Source Title: Nature Communications
URI: https://scholarbank.nus.edu.sg/handle/10635/175435
ISSN: 20411723
DOI: 10.1038/ncomms10531
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