Please use this identifier to cite or link to this item:
https://doi.org/10.1038/ncomms10531
DC Field | Value | |
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dc.title | Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes | |
dc.contributor.author | Imamura M. | |
dc.contributor.author | Takahashi A. | |
dc.contributor.author | Yamauchi T. | |
dc.contributor.author | Tai E.S. | |
dc.date.accessioned | 2020-09-10T01:40:13Z | |
dc.date.available | 2020-09-10T01:40:13Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Imamura M., Takahashi A., Yamauchi T., Tai E.S. (2016). Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications 7 : 10531. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms10531 | |
dc.identifier.issn | 20411723 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/175435 | |
dc.description.abstract | Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities. © 2016, Nature Publishing Group. All rights reserved. | |
dc.publisher | Nature Publishing Group | |
dc.source | Unpaywall 20200831 | |
dc.subject | diabetes | |
dc.subject | ethnic group | |
dc.subject | genetic analysis | |
dc.subject | health risk | |
dc.subject | heritability | |
dc.subject | meta-analysis | |
dc.subject | Article | |
dc.subject | ASB3 gene | |
dc.subject | ATP8B2 gene | |
dc.subject | CCDC85A gene | |
dc.subject | DMRTA1 gene | |
dc.subject | ethnic group | |
dc.subject | FAM60A gene | |
dc.subject | gene | |
dc.subject | gene locus | |
dc.subject | genetic association | |
dc.subject | genetic susceptibility | |
dc.subject | genotype | |
dc.subject | human | |
dc.subject | INAFM2 gene | |
dc.subject | Japanese (people) | |
dc.subject | major clinical study | |
dc.subject | meta analysis | |
dc.subject | MIR4686 gene | |
dc.subject | non insulin dependent diabetes mellitus | |
dc.subject | single nucleotide polymorphism | |
dc.subject | Asian continental ancestry group | |
dc.subject | case control study | |
dc.subject | genetic predisposition | |
dc.subject | genetics | |
dc.subject | genome-wide association study | |
dc.subject | Japan | |
dc.subject | non insulin dependent diabetes mellitus | |
dc.subject | Japan | |
dc.subject | ASB3 protein, human | |
dc.subject | DMRTA1 protein, human | |
dc.subject | DNA binding protein | |
dc.subject | FAM60A protein, human | |
dc.subject | suppressor of cytokine signaling | |
dc.subject | transcription factor | |
dc.subject | Asian Continental Ancestry Group | |
dc.subject | Case-Control Studies | |
dc.subject | Diabetes Mellitus, Type 2 | |
dc.subject | DNA-Binding Proteins | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Humans | |
dc.subject | Japan | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Suppressor of Cytokine Signaling Proteins | |
dc.subject | Transcription Factors | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1038/ncomms10531 | |
dc.description.sourcetitle | Nature Communications | |
dc.description.volume | 7 | |
dc.description.page | 10531 | |
Appears in Collections: | Staff Publications Elements |
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