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https://doi.org/10.1186/s12879-019-3705-0
Title: | Sub-clinical abnormalities detected by PET/MRI in household tuberculosis contacts | Authors: | Molton, J.S Thomas, B.A Pang, Y Khor, L.K Hallinan, J Naftalin, C.M Totman, J.J Townsend, D.W Lim, T.K Chee, C.B.E Wang, Y.T Paton, N.I |
Keywords: | fluorodeoxyglucose f 18 isoniazid fluorodeoxyglucose f 18 radiopharmaceutical agent adult aged Article clinical article clinical assessment controlled study coughing disease duration exposure female hilar lymph node household household contact human interferon gamma release assay lung disease lung nodule lymph node male maximum standardized uptake value mediastinum lymph node metabolic disorder nuclear magnetic resonance imaging positron emission tomography subclinical lung abnormality thorax radiography tuberculosis contact examination diagnostic imaging family size lung tuberculosis middle aged nuclear magnetic resonance imaging pathology positron emission tomography transmission young adult Adult Aged Contact Tracing Family Characteristics Female Fluorodeoxyglucose F18 Humans Lymph Nodes Magnetic Resonance Imaging Male Middle Aged Positron-Emission Tomography Radiopharmaceuticals Tuberculosis, Pulmonary Young Adult |
Issue Date: | 2019 | Citation: | Molton, J.S, Thomas, B.A, Pang, Y, Khor, L.K, Hallinan, J, Naftalin, C.M, Totman, J.J, Townsend, D.W, Lim, T.K, Chee, C.B.E, Wang, Y.T, Paton, N.I (2019). Sub-clinical abnormalities detected by PET/MRI in household tuberculosis contacts. BMC Infectious Diseases 19 (1) : 3705. ScholarBank@NUS Repository. https://doi.org/10.1186/s12879-019-3705-0 | Abstract: | Background: The understanding of early events following TB exposure is limited by traditional tests that rely on detection of an immune response to infection, which is delayed, or on imaging tests with low sensitivity for early disease. We investigated for evidence of lung abnormalities in heavily exposed TB contacts using PET/MRI. Methods: 30 household contacts of 20 index patients underwent clinical assessment, IGRA testing, chest x-ray and PET/MRI scan using 18-F-FDG. MRI images were examined by a radiology/nuclear medicine dual-qualified physician using a standardised report form, while PET/MRI images were examined independently by another radiology/nuclear medicine dual-qualified physician using a similar form. Standardised uptake value (SUV) was quantified for each abnormal lesion. Results: IGRA was positive in 40%. PET/MRI scan was abnormal in 30%, predominantly FDG uptake in hilar or mediastinal lymph nodes and lung apices. We did not identify any relationship between PET/MRI findings and degree of exposure or IGRA status. Conclusion: PET-based imaging may provide important insights into the natural history following exposure to TB that may not be available from traditional tests of TB immune response or imaging. The clinical significance of the abnormalities is uncertain and merits further investigation in longitudinal studies. © 2019 The Author(s). | Source Title: | BMC Infectious Diseases | URI: | https://scholarbank.nus.edu.sg/handle/10635/175340 | ISSN: | 1471-2334 | DOI: | 10.1186/s12879-019-3705-0 |
Appears in Collections: | Staff Publications Elements |
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