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https://doi.org/10.1039/c4cc04555f
| Title: | Facile regiospecific synthesis of 2,3-disubstituted indoles from isatins | Authors: | Dou, X Yao, W Wen, S Lu, Y |
Keywords: | borane derivative Grignard reagent indole derivative isatin derivative indole derivative isatin article drug industry facile regiospecific synthesis medicinal chemistry reduction synthesis chemistry enzyme specificity stereoisomerism Chemistry Techniques, Synthetic Indoles Isatin Stereoisomerism Substrate Specificity |
Issue Date: | 2014 | Publisher: | Royal Society of Chemistry | Citation: | Dou, X, Yao, W, Wen, S, Lu, Y (2014). Facile regiospecific synthesis of 2,3-disubstituted indoles from isatins. Chemical Communications 50 (67) : 9469-9472. ScholarBank@NUS Repository. https://doi.org/10.1039/c4cc04555f | Abstract: | A facile regiospecific synthesis of 2,3-disubstituted indoles from isatins has been developed. Nucleophilic addition of Grignard reagents to commercially available isatins, followed by reduction with borane, afforded an array of structurally diverse 2,3-disubstituted indoles in moderate to good yields. The method described herein represents a novel and very simple approach to synthesize various 2,3-disubstituted indoles, extremely important structural motifs in the pharmaceutical industry and medicinal chemistry. This journal is © the Partner Organisations 2014. | Source Title: | Chemical Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/175306 | ISSN: | 1359-7345 | DOI: | 10.1039/c4cc04555f |
| Appears in Collections: | Staff Publications Elements |
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