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https://doi.org/10.1128/JVI.01404-16
Title: | Evidence for the introduction, reassortment, and persistence of diverse influenza a viruses in Antarctica | Authors: | Hurt, A.C Su, Y.C.F Aban, M Peck, H Lau, H Baas, C Deng, Y.-M Spirason, N Ellström, P Hernandez, J Olsen, B Barr, I.G Vijaykrishna, D Gonzalez-Acuna, D |
Keywords: | sialidase virus antibody A(H11) influenza virus Antarctica Article controlled study gene sequence Influenza A virus Influenza A virus (H11N2) Influenza A virus (H5N5) neuraminidase gene nonhuman NP gene penguin phylogeny prevalence priority journal reverse transcription polymerase chain reaction sequence analysis serology virus gene virus genome animal avian influenza bird Canada genetic variation genetics Influenza A virus isolation and purification virology wild animal Animals Animals, Wild Birds Canada Genes, Viral Genetic Variation Influenza A virus Influenza in Birds Phylogeny Spheniscidae |
Issue Date: | 2016 | Publisher: | American Society for Microbiology | Citation: | Hurt, A.C, Su, Y.C.F, Aban, M, Peck, H, Lau, H, Baas, C, Deng, Y.-M, Spirason, N, Ellström, P, Hernandez, J, Olsen, B, Barr, I.G, Vijaykrishna, D, Gonzalez-Acuna, D (2016). Evidence for the introduction, reassortment, and persistence of diverse influenza a viruses in Antarctica. Journal of Virology 90 (21) : 9674-9682. ScholarBank@NUS Repository. https://doi.org/10.1128/JVI.01404-16 | Abstract: | Avian influenza virus (AIV) surveillance in Antarctica during 2013 revealed the prevalence of evolutionarily distinct influenza viruses of the H11N2 subtype in Adélie penguins. Here we present results from the continued surveillance of AIV on the Antarctic Peninsula during 2014 and 2015. In addition to the continued detection of H11 subtype viruses in a snowy sheathbill during 2014, we isolated a novel H5N5 subtype virus from a chinstrap penguin during 2015. Gene sequencing and phylogenetic analysis revealed that the H11 virus detected in 2014 had a >99.1% nucleotide similarity to the H11N2 viruses isolated in 2013, suggesting the continued prevalence of this virus in Antarctica over multiple years. However, phylogenetic analysis of the H5N5 virus showed that the genome segments were recently introduced to the continent, except for the NP gene, which was similar to that in the endemic H11N2 viruses. Our analysis indicates geographically diverse origins for the H5N5 virus genes, with the majority of its genome segments derived from North American lineage viruses but the neuraminidase gene derived from a Eurasian lineage virus. In summary, we show the persistence of AIV lineages in Antarctica over multiple years, the recent introduction of gene segments from diverse regions, and reassortment between different AIV lineages in Antarctica, which together significantly increase our understanding of AIV ecology in this fragile and pristine environment. © 2016, American Society for Microbiology. | Source Title: | Journal of Virology | URI: | https://scholarbank.nus.edu.sg/handle/10635/175266 | ISSN: | 0022-538X | DOI: | 10.1128/JVI.01404-16 |
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