Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00018-016-2406-8
Title: H2S biosynthesis and catabolism: new insights from molecular studies
Authors: Rose P.
Moore P.K. 
Zhu Y.Z. 
Keywords: 3 mercaptopyruvate sulfurtransferase
cystathionine beta synthase
cystathionine gamma lyase
cysteine dioxygenase
hydrogen sulfide
immunoglobulin enhancer binding protein
reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone)
sulfide
3-mercaptopyruvate sulphurtransferase
cystathionine beta synthase
cysteine dioxygenase
dioxygenase
ETHE1 protein, mouse
hydrogen sulfide
lyase
mitochondrial protein
O-succinylhomoserine (thiol)-lyase
reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone)
sulfide quinone reductase
sulfurtransferase
biosynthesis
brain disease
catabolism
chemical structure
detoxification
disease association
disease model
disease predisposition
enzyme activity
gas analysis
human
in vivo study
nonhuman
protein expression
Review
site directed mutagenesis
transgenic animal
upregulation
animal
gene expression regulation
gene inactivation
genetics
metabolism
procedures
signal transduction
Animals
Biosynthetic Pathways
Carbon-Oxygen Lyases
Cystathionine beta-Synthase
Cysteine Dioxygenase
Dioxygenases
Gene Expression Regulation
Gene Knockout Techniques
Humans
Hydrogen Sulfide
Mitochondrial Proteins
Quinone Reductases
Signal Transduction
Sulfurtransferases
Issue Date: 2017
Publisher: Birkhauser Verlag AG
Citation: Rose P., Moore P.K., Zhu Y.Z. (2017). H2S biosynthesis and catabolism: new insights from molecular studies. Cellular and Molecular Life Sciences 74 (8) : 1391-1412. ScholarBank@NUS Repository. https://doi.org/10.1007/s00018-016-2406-8
Abstract: Hydrogen sulfide (H2S) has profound biological effects within living organisms and is now increasingly being considered alongside other gaseous signalling molecules, such as nitric oxide (NO) and carbon monoxide (CO). Conventional use of pharmacological and molecular approaches has spawned a rapidly growing research field that has identified H2S as playing a functional role in cell-signalling and post-translational modifications. Recently, a number of laboratories have reported the use of siRNA methodologies and genetic mouse models to mimic the loss of function of genes involved in the biosynthesis and degradation of H2S within tissues. Studies utilising these systems are revealing new insights into the biology of H2S within the cardiovascular system, inflammatory disease, and in cell signalling. In light of this work, the current review will describe recent advances in H2S research made possible by the use of molecular approaches and genetic mouse models with perturbed capacities to generate or detoxify physiological levels of H2S gas within tissues. © 2016, The Author(s).
Source Title: Cellular and Molecular Life Sciences
URI: https://scholarbank.nus.edu.sg/handle/10635/175231
ISSN: 1420-682X
DOI: 10.1007/s00018-016-2406-8
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